Type 2 Usher Syndrome - A Cause for Sensorineural Hearing Loss.

Usher syndrome is a genetic condition involving Sensorineural hearing loss and Retinitis pigmentosa (RP). Although considered a rare disease, it is the most frequent cause of deaf- blindness in humans. It is inherited in an autosomal recessive pattern.

The Patient Population at Homeopathic Outpatient Clinics across India: A Clinical Data Collection Study.

Background:  Even though several initiatives have been undertaken in different locations worldwide to collect clinical data in homeopathy, it is important to further investigate these aspects in the context of health care in India.

Objective:  The study aimed to gather and analyze patients' clinical data and to derive insights into homeopathic treatment using an internet-based software program for data storage, retrieval and repertorization.

Methods:  A multi-center observational study was conducted across 14 homeopathy outpatient clinics in India that are affiliated with the Central Council for Research in Homoeopathy (CCRH).

Dynamic Covalent Bonds in the Ebselen Class of Antioxidants Probed by X-ray Quantum Crystallography.

Dynamic bonds are essential structural ingredients of dynamic covalent chemistry that involve reversible cleavage and formation of bonds. Herein, we explore the electronic characteristics of Se-N bonds in the organo-selenium antioxidant ebselen and its derivatives for their propensity to function as dynamic covalent bonds by employing high-resolution X-ray quantum crystallography and complementary computational studies. An analysis of the experimentally reconstructed X-ray wavefunctions reveals the salient electronic features of the Se-N bonds with very low electron density localized at the bonding region and a positive Laplacian value at the bond critical point.

Magnetically tunable ultralow threshold optical bistability by exciting LRSPR in InAs/graphene layers at the terahertz region.

With the experimental corroboration employing a transfer matrix method, an analytical observation of optical bistability using long-range surface plasmon resonance (LRSPR) through the external magnetic field is presented for a very low threshold value. The proposed analytical method has been verified with the reported experimental data provided by Liu et al. [Curr.

Transcriptomics, Cheminformatics, and Systems Pharmacology Strategies Unveil the Potential Bioactives to Combat COVID-19.

Coronavirus disease (COVID-19) is a viral disease caused by the SARS-CoV-2 virus and is becoming a global threat again because of the higher transmission rate and lack of proper therapeutics as well as the rapid mutations in the genetic pattern of SARS-CoV-2. Despite vaccinations, the prevalence and recurrence of this infection are still on the rise, which urges the identification of potential global therapeutics for a complete cure. Plant-based alternative medicine is becoming popular worldwide because of its higher efficiency and minimal side effects.

A quantitative method for the detection and validation of catalase activity at physiological concentration in human serum, plasma and erythrocytes.

A novel method has been proposed to develop a simple, rapid, sensitive and affordable chromogenic attempt for the quantification of catalase (CAT) activity in blood samples. The method is based on the oxidation of pyrocatechol (PC) to give quinone form which by oxidative coupling with aminyl radical of 4-aminoantipyrine (4-AAP) resulting from HO/CAT to produce a pink colored quinone-imine product with λ = 530 nm in a 100 mmol/L of tris buffer of pH 9.8 at room temperature (30 °C).

Evaluation of the Effect of Fluoride-containing Luting Cements on Titanium and Its Effect on the Shear Bond Strength.

Context: The most appropriate luting agent for titanium crowns is yet to be determined. Commonly used cements for luting titanium restorations give off leachable ions which may cause surface interaction with the titanium.

Aims: The purpose of this study was to determine the shear bond strength of four grades of commercially pure titanium and Ti 6Al 4V with different cements and to examine for any surface physical changes.

Methods of Isolation and Characterization of Stem Cells from Different Regions of Oral Cavity Using Markers: A Systematic Review.

Background: Periodontitis is a destructive inflammatory disorder of the periodontium caused by the destruction of periodontal tissues namely the PDL, cementum, alveolar bone, and gingiva. Once these tissues are lost, the foremost goal of periodontal therapy is to regenerate the diseased tissues if possible to their original form, architecture, and function. Various regenerative procedures were employed and still a gap was found in achieving the goal.

Anaplastic hemangiopericytoma in the frontal horn of the lateral ventricle.

Intracranial hemangiopericytomas are uncommon tumors, and their intraventricular occurrence is even rarer. We report a 40-year-old man who presented with raised intracranial pressure. His MRI showed a 3.

Infected cervico-dorsal dermoid cyst with fluid - fluid level.

We report a case of a 22-year-old female who was operated at the age of 3 months for cervico-dorsal swelling. She presented with gradual onset, progressively worsening dull aching pain in the cervico-dorsal region, 21 years following previous surgery. Magnetic resonance imaging showed intradural dermoid cyst with the fluid level.

Cavernoma of the septum pellucidum in the region of foramen of Monro.

A rare case of cavernoma in the region of the septum pellucidum is reported. A 35-year-old female patient presented with chronic headaches. Her neurological exam was normal.

Cranial dural arteriovenous shunts. Part 2. The shunts of the bridging veins and leptomeningeal venous drainage.

Leptomeningeal venous drainage of cranial dural arteriovenous fistulae is the most important determinant of adverse clinical course. Factors that predispose to its occurrence have not been adequately addressed in the literature. In the present study, we investigated the relation of shunt location to the development of leptomeningeal venous drainage, with regard to the bridging veins.

Plasma heating by electric field compression.

Plasma heating by compression of electric fields is proposed. It is shown that periodic cycles of external compression followed by the free expansion of electric fields in the plasma cause irreversible, collisionless plasma heating and corresponding entropy generation. As a demonstration of general ideas and scalings, the heating is shown in the case of a dusty plasma, where electric fields are created due to the presence of charged dust.

Thermal energy density of dust in dusty plasmas: experiment and theory.

A surprising observation in dusty plasma experiments is that the dust thermal energy density, P_{d}∝n_{d}T_{d}, is typically much greater than n_{d}T_{n} (where n_{d} and T_{d} are the dust density and temperature, and T_{n} is the neutral temperature), even though the dust particles would be expected to be in thermal equilibrium with the neutrals. We show here, theoretically and experimentally, that the anomalously high dust thermal energy density can be accounted for if electrostatic interactions between the dust particles and the background plasma are taken into account. Thus, the dust pressure in dusty plasma is mostly of electrostatic origin.

Quantification of creatinine in biological samples based on the pseudoenzyme activity of copper-creatinine complex.

Glomerular filtration rate (GFR), the marker of chronic kidney disease can be analyzed by the concentration of cystatin C or creatinine and its clearance in human urine and serum samples. The determination of cystatin C alone as an indicator of GFR does not provide high accuracy, and is more expensive, thus measurement of creatinine has an important role in estimating GFR. We have made an attempt to quantify creatinine based on its pseudoenzyme activity of creatinine in the presence of copper.

Phase coexistence and a critical point in ultracold neutral plasmas.

We show the existence of the liquid-vapor phase coexistence and a critical point for strongly coupled ions in ultracold neutral (UCN) plasmas. Expressions for the free energy of UCN plasmas and an equation of state for the ions are obtained in the mean field approximation. A van der Waals-like isotherm shows the existence of a critical point in UCN plasmas.

Determination of catalase activity using chromogenic probe involving iso-nicotinicacidhydrazide and pyrocatechol.

A biocatalatic pathway involving chromogenic probe has been proposed for the determination of catalase activity by means of iso-nicotinicacidhydrazide (INH) and pyrocatechol (PC). The assay is based on the enzymatic consumption of hydrogen peroxide using INH-PC system. The response of the catalase activity was ascertained by the rate of the reaction involving 14.

Simple and sensitive method for the quantification of total bilirubin in human serum using 3-methyl-2-benzothiazolinone hydrazone hydrochloride as a chromogenic probe.

We here describe a new spectrophotometric method for measuring total bilirubin in serum. The method is based on the cleavage of bilirubin giving formaldehyde which further reacts with diazotized 3-methyl-2-benzothiazolinone hydrazone hydrochloride giving blue colored solution with maximum absorbance at 630 nm. Sensitivity of the developed method was compared with Jendrassik-Grof assay procedure and its applicability has been tested with human serum samples.

Chronic intradiploic hematoma in patients with coagulopathy.

Intradiploic hematomas occur rarely. They have been reported in patients with and without coagulation disorders. The presentation of intradiploic hematomas varies depending on their location and the severity of the coagulopathy.

Magnetic resonance imaging in acute cervical spinal cord injury: a correlative study on spinal cord changes and 1 month motor recovery.

Study Design: Retrospective study.

Objectives: We aimed to correlate the spinal cord changes as depicted by magnetic resonance imaging (MRI) with the neurological deficit and motor recovery of patients with acute cervical spinal cord injury (SCI).

Setting: A total of 57 patients with acute cervical spine trauma who presented to the Department of Radio Diagnosis, Kasturba Medical College Manipal, Karnataka, India, over a period of 5 years (August 2002 to September 2007) were studied.

Computed tomographic features of mandibular osteochondroma.

Osteochondroma of the mandibular condyle is fairly rare. We describe a case of this lesion in a 52-year-old woman who presented with symptoms of temporomandibular joint dysfunction. Although a panoramic radiograph demonstrated the bony exostosis, a pre-operative CT examination showed the relationship of the tumour to the condyle and also depicted soft-tissue changes secondary to the growth.

Extracranial meningioma of the parapharyngeal space: report of a case and review of the literature.

Parapharyngeal tumours are frequently encountered in clinical practice and are often difficult to diagnose upon clinical examination due to the anatomic complexity of the region. We report a rare case of extracranial meningioma of the parapharyngeal space in a patient with no history of von Recklinghausen's disease, family history of meningioma or central neurofibromatosis (NF-2). The purpose of this report is to reiterate and emphasize the role of CT and MRI in the diagnosis of parapharyngeal masses, and to describe the characteristic radiological features of extracranial meningiomas.

Mean-field theory of critical phenomenon for mutually repelling particles in complex plasmas.

A mean-field theory of criticality for charged particles in complex plasmas is proposed. It is shown that the existence of the critical point and the liquid-vapor coexistence is fully consistent with a purely repulsive potential between particles; the cohesive field due to the plasma background drives these. The critical exponents, calculated by expanding the free energy near the critical point, are found to be classical.