Class III Correction With Reverse Twin Block-A Case Report.

The orthodontic management of patients with Class III malocclusion poses numerous treatment challenges. Various removable, fixed, orthopedic, and myofunctional appliances have been recommended for its correction. The Reverse Twin Block is a removable appliance which has been used for the early management of such cases.

A Retrospective Study Comparing Nose, Lip, and Chin Morphology in Class I, Class II, and Class III Skeletal Relationships in Patients Visiting to the Department of Orthodontics, BPKIHS: A Cephalometric Study.

Background: With the changing paradigm from primarily hard tissue to soft tissue evaluation for orthodontic diagnosis and treatment planning, the priority has shifted to bring about improvement in the profile and smile characteristics of patients. Since not only the esthetics but also the stability of orthodontic treatment is largely determined by the soft tissue envelope, proper positioning of the soft tissue drape becomes paramount. Soft tissues of face, namely, nose, lips, and chin, are of paramount importance not only from an esthetic but also from functional and treatment stability points.

Thermite reaction driven pyrotechnic formulation with promising functional performance and reduced emissions.

Green pyrotechnics/firecrackers reported herein are driven by thermite reactions for self-contained and self-sustained exothermic chemical reactions to make heat and sound by the usage of minimal fuel (aluminum), oxidizer (potassium nitrate), and Sulfur. These firecrackers have the potential for generating less emissions (70%) compared to commercial firecracker-based counterparts due to the presence of additives and are therefore designated as "Green firecrackers" or reduced emissions firecrackers. The functional performance and long-term stability of the composition was investigated through sound measurement and different tests, including ageing, thermal stability, and moisture test.

Development of Darunavir proliposome powder for oral delivery by using Box-Bhenken design.

The aim of this study is to develop Darunavir (DRV) proliposome powder for oral delivery. Darunavir-loaded oral proliposome powder (OPP) was prepared by a solvent evaporation technique with varying independent variables at three different levels. Based on different levels, proliposome powder formulation was optimized by using Box-Behnken design.

Development of α-glucosidase inhibitors by room temperature C-C cross couplings of quinazolinones.

Novel quinazolinone based α-glucosidase inhibitors have been developed. For this purpose a virtual screening model has been generated and validated utilizing acarbose as a α-glucosidase inhibitor. Homology modeling, docking, and virtual screening were successfully employed to discover a set of structurally diverse compounds active against α-glucosidase.

C-C cross-coupling reactions of O6-alkyl-2-haloinosine derivatives and a one-pot cross-coupling/O6-deprotection procedure.

Reaction conditions for the CC cross-coupling of O(6)-alkyl-2-bromo- and 2-chloroinosine derivatives with aryl-, hetaryl-, and alkylboronic acids were studied. Optimization experiments with silyl-protected 2-bromo-O(6)-methylinosine led to the identification of [PdCl(2)(dcpf)]/K(3)PO(4) in 1,4-dioxane as the best conditions for these reactions (dcpf=1,1'-bis(dicyclohexylphosphino)ferrocene). Attempted O(6)-demethylation, as well as the replacement of the C-6 methoxy group by amines, was unsuccessful, which led to the consideration of Pd-cleavable groups such that C-C cross-coupling and O(6)-deprotection could be accomplished in a single step.