Publications by authors named "Avinash A Kadam"

Intensified agrochemical-based monoculture systems worldwide are under adoption to meet the challenge of human population growth and the ever-growing global demand for food. However, this path has been opposed and criticized because it involves overexploitation of land, monoculture of few species, excessive input of agrochemicals, and adverse impacts on human health and the environment. The wide diversity among polyculture systems practiced across the globe has created confusion over the priority of a single strategy towards sustainable aquaculture development and safer products.

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Coronavirus disease 2019 (COVID-19) is now being investigated for its distinctive patterns in the course of disease development which can be indicated with miscellaneous immune responses in infected individuals. Besides this series of investigations on the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), significant fundamental immunological and physiological processes are indispensable to address clinical markers of COVID-19 disease and essential to identify or design effective therapeutics. Recent developments in the literature suggest that deficiency of type I interferon (IFN) in serum samples can be used to represent a severe progression of COVID-19 disease and can be used as the basis to develop combined immunotherapeutic strategies.

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Article Synopsis
  • Researchers are exploring bioplastics, particularly polyhydroxyalkanoates (PHA), using sugarcane bagasse waste, focusing on individual and co-culture microbial strains RGS and ATCC 17699.
  • Acidic and acidified sodium chlorite treatments effectively hydrolyzed the sugarcane bagasse, achieving significant delignification and maximizing hydrolysis and saccharification yields.
  • The study shows that using a co-culture approach with nutrient supplements like corn steep liquor and spent coffee oil enhances cell growth and PHA production, suggesting a viable method for producing bioplastics from agricultural waste.
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This study explored the potential of abundantly available sodium lignosulfonate (LS) as a reducer and fabricating agent in preparing silver nanoparticles (LS-Ag NPs). The operational conditions were optimized to make the synthesis process simpler, rapid, and eco-friendly. The prepared LS-Ag NPs were analyzed via UV-Vis spectroscopy, X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, and high-resolution transmission electron microscopy.

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Global energy consumption has been increasing in tandem with economic growth motivating researchers to focus on renewable energy sources. Dark fermentative hydrogen synthesis utilizing various biomass resources is a promising, less costly, and less energy-intensive bioprocess relative to other biohydrogen production routes. The generated acidogenic dark fermentative effluent [e.

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Brassinosteroids (BRs) play crucial roles in various biological processes, including plant developmental processes and response to diverse biotic and abiotic stresses. However, no information is currently available about this gene family in wheat ( L.).

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PIN-FORMED (PIN) genes play a crucial role in regulating polar auxin distribution in diverse developmental processes, including tropic responses, embryogenesis, tissue differentiation, and organogenesis. However, the role of PIN-mediated auxin transport in various plant species is poorly understood. Currently, no information is available about this gene family in wheat ( L.

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The utilization of waste-paper-biomass for extraction of important α-cellulose biopolymer, and modification of extracted α-cellulose for application in enzyme immobilization can be extremely vital for green circular bio-economy. Thus, in this study, α-cellulose fibers were super-magnetized (FeO), grafted with chitosan (CTNs), and thiol (-SH) modified for laccase immobilization. The developed material was characterized by high-resolution transmission electron microscopy (HR-TEM), HR-TEM energy dispersive X-ray spectroscopy (HR-TEM-EDS), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FT-IR) analyses.

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Polyhydroxyalkanoates (PHA) are appealing as an important alternative to replace synthetic plastics owing to its comparable physicochemical properties to that of synthetic plastics, and biodegradable and biocompatible nature. This review gives an inclusive overview of the current research activities dealing with PHA production by utilizing different waste fluxes generated from food, milk and sugar processing industries. Valorization of these waste fluxes makes the process cost effective and practically applicable.

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Existing coronavirus named as a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has speeded its spread across the globe immediately after emergence in China, Wuhan region, at the end of the year 2019. Different techniques, including genome sequencing, structural feature classification by electron microscopy, and chest imaging using computed tomography, are primarily used to diagnose and screen SARS-CoV-2 suspected individuals. Determination of the viral structure, surface proteins, and genome sequence has provided a design blueprint for the diagnostic investigations of novel SARS-CoV-2 virus and rapidly emerging diagnostic technologies, vaccine trials, and cell-entry-inhibiting drugs.

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This study focuses on the development of a nanosupport based on halloysite nanotubes (HNTs), FeO nanoparticles (NPs), and thiolated chitosan (CTs) for laccase immobilization. First, HNTs were modified with FeO NPs (HNTs-FeO) by the coprecipitation method. Then, the HNTs-FeO surface was tuned with the CTs (HNTs-FeO-CTs) by a simple refluxing method.

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Article Synopsis
  • Removal of biofilms is crucial in both environmental and medical contexts, making research on effective enzyme combinations for disrupting them very important.
  • The study focused on a specific enzyme, protease from bovine pancreas type-I (PtI), and its anti-biofilm effects, both alone and in combination with another enzyme, α-amylase (αA).
  • Results showed that PtI alone had strong biofilm inhibition against multiple bacteria, while the combination of PtI and αA further enhanced these effects, suggesting their potential utility in treating biofilm-related infections, especially those caused by MRSA.
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A surface-engineered nano-support for enzyme laccase-immobilization was designed by grafting the surface of halloysite nanotubes (HNTs) with FeO nanoparticles and chitosan. Herein, HNTs were magnetized (HNTs-M) by a cost-effective reduction-precipitation method. The synthesized HNTs-M were grafted with 0.

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Hydrothermally carbonized sugarcane bagasse (SCB) has exceptional surface properties. Looking at the huge amount of SCB produced, its biocompatible nature, cheap-cost for carbonization, and its easy functionalization can give impeccable nano-biomaterials for tissue engineering applications. Herein, sugarcane bagasse was converted into hydrochar (SCB-H) by hydrothermal carbonation.

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This study demonstrates a green-route-based synthesis of high-concentration suspensions of anisotropic silver nanoparticles (AgNPs) by peptone (Pep), a soluble protein hydrolysate and an abundantly used nutrient source in microbial-media. The transformation of Ag ions from solution into a high-concentration suspension of anisotropic Pep-AgNPs, at an extremely low concentration of peptone (0.02%), indicates that the present green-route synthesis method follows "low volume high concentration nano-synthesis", and, hence, enhances the economic significance of the process.

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Halloysite nanotubes (HNTs) are known to be the highly emerging materials in nano-medicinal applications. However, comprehensive exploitation of HNTs for the regenerative medicinal applications is still necessary to be done. Therefore, towards enhancing the osteogenic potential of human adipose tissue-derived mesenchymal stem cells (hADMSCs), this study synthesized a novel and multifunctional nanoscaffold of chitosan (CTs) functionalized supermagnetic halloysite nanotubes (M-HNTs) decorated with the calcium phosphate 2-D nanoflakes (CaP) (termed as; M-HNTs-CTs-CaP).

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In these studies, we analyzed substituted piperazine based berberine analogs conjugated through a pentyloxy side chain for their in vitro and in silico biological effects. All the final analogs were screened for their in vitro antiviral action against a collection of different influenza virus strains using the CPE assay and SRB assay. Moreover, their cytotoxicity towards non-cancer cell lines was examined employing Madin-Darby canine kidney (MDCK) cell lines.

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We developed a colorimetric method for the rapid detection of copper ions (Cu) in aqueous solution. The detection of Cu is based on coordination reactions of Cu with casein peptide-functionalized silver nanoparticles (AgNPs), leading to a distinct color change of the solution from yellow to red. The developed method has a good detection limit of about 0.

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Owing to the ubiquitous availability and simple biocatalysis, the anti-proliferative laccase holds enormous opportunities for anti-cancer applications. However, accessing efficient and specific (super-magnetically targetable) new delivery system for anti-proliferative laccase is vital step towards laccase based anti-cancer approach. Therefore, in this investigation, super-magnetized (FeO) and chitosan (CS) functionalized halloysite nanotubes (HNTs) (termed as FeO-HNTs-CS) was facile synthesized.

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Halloysite nanotubes (HNTs) were modified with supermagnetic FeO (M-HNTs) and functionalized with chitosan (CTA) (termed as M-HNTs-CTA). Furthermore, M-HNTs-CTA were cross-linked using glutaraldehyde and applied for covalent laccase immobilization (M-HNTs-CTA-Lac). Facile-synthesized modified HNTs were structurally characterized by scanning electron microscopy, high resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and thermogravimetric analyses.

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Enormous disposal of paper wastes (PW) causing number of environmental problems. PW is efficiently used to extract multifunctional α-cellulose fibers (αCFs). Thus, αCFs extraction from PW, and functionalization with FeO and chitosan were successfully performed for immobilization of laccase.

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Background: Berberine, a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids has drawn high attention for its several biological potencies.

Objective: To furnish new rationalized derivatives based on berberine core which can deliver promising antioxidant and cytotoxic activities.

Method: The N-Mannich base of an isoquinoline alkaloid, berberine, bearing substituted benzothiazole moieties was obtained.

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Halloysite nanotubes (HNTs) were tuned with supermagnetic FeO (M-HNTs) and functionalized with γ-aminopropyltriethoxysilane (APTES) (A-M-HNTs). Gluteraldehyde (GTA) was linked to A-M-HNTs (A-M-HNTs-GTA) and explored for covalent laccase immobilization. The structural characterization of M-HNTs, A-M-HNTs, and A-M-HNTs-GTA-immobilized laccase (A-M-HNTs-GTA-Lac) was determined by X-ray photoelectron spectroscopy, field-emission high-resolution transmission electron microscopy, a magnetic property measurement system, and thermogavimetric analyses.

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