Significance of the tethered maxillary frenulum: a questionnaire-based observational cohort study.

Background: The clinical significance of lip-tie, or a tethered maxillary frenulum, remains under debate. Clinicians and parents are often perplexed when deciding whether procedures available to relieve a seemingly tight or severe maxillary frenulum are needed.

Purpose: No previous studies have assessed the consequences of not subjecting a tethered maxillary frenulum in newborns to surgical intervention.

Calcium level during the first trimester of pregnancy as a predictor of preeclampsia.

Objective: To examine the association between calcium levels during the first trimester of pregnancy and preeclampsia.

Methods: The study population included registered births (n = 5233) in a tertiary medical center between 2001 and 2011. A comparison was performed between women with and without hypocalcemia during the first trimester of pregnancy.