Publications by authors named "Avia Abramovitz Fouks"
Article Synopsis
- The study investigates the effectiveness of left atrial appendage closure (LAAC) in preventing recurrent strokes in patients with nonvalvular atrial fibrillation (NVAF) who experience acute ischemic strokes (AIS) despite being on oral anticoagulants (OAC).
- Over a follow-up period of approximately 1.75 years, the incidence of AIS after LAAC was significantly lower (1.97%) than the expected stroke risk based on patients' CHADS-VASc scores (8.44%), suggesting LAAC could be beneficial.
- These findings indicate a need for further randomized trials to explore the potential advantages of LAAC in this high-risk patient population, especially given that many patients discontinued OAC after
Article Synopsis
- The study focused on patients with non-valvular atrial fibrillation (NVAF) at high risk of intracranial hemorrhage (ICH) who underwent left atrial appendage closure (LAAC) due to prior ICH or high-risk MRI findings.
- Over a mean follow-up of 2.12 years, results showed that these patients had a low incidence of recurrent ICH and ischemic stroke post-procedure, suggesting LAAC is a safe option.
- The findings support the inclusion of LAAC in treatment plans for high ICH risk patients as endorsed by FDA approval and recent guidelines.
Background: Evidence from animal studies suggests that minocycline may reduce lobar intracerebral hemorrhage (ICH) recurrence in cerebral amyloid angiopathy, possibly by inhibiting perivascular extracellular matrix degradation in cerebral small vessels. There is currently no evidence of its safety or efficacy in humans with cerebral amyloid angiopathy.
Methods And Results: To provide preliminary data to support future studies of minocycline's efficacy, the authors performed a retrospective single-center cohort study to assess the incidence of recurrent ICH in patients with an aggressive clinical course of probable cerebral amyloid angiopathy who had been prescribed minocycline off-label via shared decision-making.
Background: Ischemic strokes (IS) occurring in patients taking non-vitamin K antagonist oral anticoagulants (NOACs) are becoming increasingly more frequent. We aimed to determine the clinical, echocardiographic, and neuroimaging markers associated with developing IS in patients taking NOACs for atrial fibrillation.
Methods: From a quaternary care center, clinical/radiologic data were collected from consecutive NOAC users with IS and age-matched controls without IS.
Background And Objectives: Hypertensive cerebral small vessel disease (HTN-cSVD) is the predominant microangiopathy in patients with a combination of lobar and deep cerebral microbleeds (CMBs) and intracerebral hemorrhage (mixed ICH). We tested the hypothesis that cerebral amyloid angiopathy (CAA) is also a contributing microangiopathy in patients with mixed ICH with cortical superficial siderosis (cSS), a marker strongly associated with CAA.
Methods: Brain MRIs from a prospective database of consecutive patients with nontraumatic ICH admitted to a referral center were reviewed for the presence of CMBs, cSS, and nonhemorrhagic CAA markers (lobar lacunes, centrum semiovale enlarged perivascular spaces [CSO-EPVS], and multispot white matter hyperintensity [WMH] pattern).