Publications by authors named "Avery Tran"
Article Synopsis
- Cells in confined spaces face mechanical challenges that impact their migration, but the exact effects on their migration machinery are not fully understood.
- Research shows that a protein called anillin, which regulates cytokinesis, is retained in the cytoplasm during interphase and is recruited to the edges of cells when they migrate in confined environments.
- Anillin works alongside another protein, Ect2, to enhance muscle contractility inside cells, which is crucial for effective invasion and movement in cancer progression.
Adv Sci (Weinh)
September 2022
Article Synopsis
- The study explores how the shape of cell nuclei changes in 3D fibrous environments that mimic natural tissue, highlighting the role of the cytoskeleton and contractility.
- Researchers use suspended nanofiber networks to analyze how the nucleus adapts to different fiber diameters, finding that larger fibers enhance contractility and cause the nucleus to take on unique shapes, like teardrops.
- The results show that while nuclei can form deep invaginations at fiber contact points, these adaptations do not lead to nucleus rupture, suggesting important implications for understanding cellular behavior in complex environments.
