Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis.

Objectives: To assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse collagen induced arthritis (mCIA) models. To explore the parameters of the targeting exhibited by anti-FnEDA mAbs including timing and location.

Methods: Targeting capabilities of anti-FnEDA mAbs were demonstrated by biodistribution study where i.