[Biosimilar of interferon-beta 1b in the treatment of multiple sclerosis and the own experience in the use of ronbetal].

The results of using ronbetal, the Russian biosimilar of interferon-beta 1b, in the treatment of multiple sclerosis (MS) are presented. The study included outpatients followed up from February 2008 to March 2012. All patients were assessed neurologically with additional evaluation using the EDSS; a number of exacerbations and their outcomes, disease progression, tolerability of the drug were recorded.

[Effect of alcoholic intoxication on the body's natural resistance to exposure to infectious and toxic agents].

The influence of alcoholic intoxication on the resistance of albino mice to bacterial toxins and staphylococcus cultures was investigated. Five-day administration of 40% ethyl alcohol to the animals was accompanied by a significant increase of their resistance to the intoxication caused by C1. perfringens toxins and staphylococcus.

[Effect of antibiotics on the resistance of white mice to infection caused by antibiotic-resistant Staphylococcus strains].

The effect of benzylpenicillin, streptomycin and tetracycline on the animal resistance to infection caused by the antibiotic resistant staphylococci was studied. It was found that the effect of the antibiotics on the infectious process outcome was not limited by their antibacterial properties. Changes in the natural resistance of the host under the effect of the antibiotics were not always the same and depended on both the antibiotic type and the moment of its administration.

[Effect of some antibiotics on the resistance of white mice to staphylococcal toxin].

Penicillin and streptomycin in experimental staphylococcal intoxication had different effects on the disease depending on the period of their use. Penicillin injections prior to administration of the toxin increased significantly the resistance of the animals to it, while with the use of streptomycin there was only a tendency to its increase. The use of both antibiotics against the background of the intoxication had a reverse effect: there was a tendency to a decreased animal resistance to a greater extent with the use of streptomycin.

[Effect of antibiotics on the resistance of white mice to C1. perfringens toxin].

The effect of potassium benzylpenicillin, streptomycin sulfate and chlortetracycline on experimental gangrenous intoxication was studied. When the antibiotics were injected before intoxication, the albino mice resistance did not significantly change. When the antibiotics were injected immediately after the toxin administration, the resistance of the test animals markedly decreased.

[Immunogenesis and nonspecific factors of natural resistance. XI. Further study of the depression mechanism of humoral reactions of natural immunity during the vaccinal process].

The mechanisms of depression of humoral reactions of natural immunity under the effect of vaccination were studied further. Experiments were carried out on albino rats tolerant to the horse serum protein. Administration of the antigen to the tolerant animals failed to cause formation of antibodies or to influence humoral factors of natural immunity.