Effect of diphenylhydantoin, granatane-3-spiro-5'-hydantoin and leptazol on mouse brain glutamate dehydrogenase, urea and ammonia levels in brain.

The effect of diphenylhydantoin (DPH), granatane-3-spiro-5'-hydantoin and leptazol has been checked on both GDH activity and ammonia and urea levels in brain. Concentrations of 90 mg/kg of leptazol decreased, significantly, the ammonium and urea levels in brain with respect to normal control. DPH and G-3SH had no effect on these metabolites against normal control.