Publications by authors named "Avedis Mardirossian"
Article Synopsis
- * A comprehensive review of literature from January 2000 to October 2020 identified 334 articles that reported 455 SNPs related to BC; however, those linked to smoking and environmental factors were excluded.
- * Ultimately, 197 genes and 343 SNPs were associated with BC, with 177 genes and 291 SNPs showing consistent findings across various studies, categorized into eight functional groups.
BMC Med Genomics
October 2022
Article Synopsis
- Bladder cancer (BC) is the 10th most common cancer worldwide and is particularly prevalent in Lebanon, but the genetic factors contributing to this high incidence among Lebanese are not well understood.
- A case-control study involving 51 patients at Hotel-Dieu de France Hospital used Whole Exome Sequencing (WES) to identify potentially cancer-associated genetic variants, comparing these findings to a control group of 472 Lebanese individuals.
- The study identified 484 polymorphisms linked to BC, with significant differences in allelic frequencies for 11 variants, but none were associated with an increased risk of BC in the Lebanese population, including a specific variant in the NAT1 gene.
