In Vitro Study of Antiviral Properties of Compounds Based on 1,4-Dioxane Derivative of Closo-Decaborate Anion with Amino Acid Ester Residues Against Influenza Virus A/IIV-Orenburg/83/2012(H1N1)pdm09.

New derivatives of the -decaborate anion [BH-O(CH)O(CH)C(O)-L-OCH] (An) (: L = Trp; : L = His; : L = Met; : L = Ala(2-oxopyrrolidin-3-yl) (Pld) were synthesized and isolated as tetraphenylphosphonium salts (PhP)An. Anions ; ; , and contain a pendant functional group from the L-tryptophan methyl ester, L-histidine methyl ester, L-methionine methyl ester, or methyl 2-amino-3-(2-oxopyrrolidin-3-yl)propanoate (-Trp-OCH, -His-OCH, -Met-OCH, or -Pld-OCH) residue, respectively, bonded with the boron cluster anion through the oxybis[(ethane-2,1-diyl)oxy] spacer. This pacer is formed as a result of the nucleophilic opening of the attached dioxane molecule in the [BHO(CH)O] starting derivative.

Compounds based on Adamantyl-substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors.

The discussion has revolved around the derivatives of amino acids and peptides containing carbocycles and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus. Studies conducted on cell cultures reveal that aminoadamantane amino acid derivatives exhibit the capacity to hinder the replication of viruses containing viroporins. Furthermore, certain compounds demonstrate potent virucidal activity with respect to influenza A/H5N1 and hepatitis C virus particles.

Composites and Materials Prepared from Boron Cluster Anions and Carboranes.

Here, we present composites and materials that can be prepared starting with boron hydride cluster compounds (decaborane, decahydro--decaborate and dodecahydro--dodecaborate anions and carboranes). Recent examples of their utilization as boron protective coatings including using them to synthesize boron carbide, boron nitride, metal borides, metal-containing composites, and neutron shielding materials are discussed. The data are generalized demonstrate the versatile application of materials based on boron cluster anions and carboranes in various fields.

[Antiviral properties of synthetic histidine derivatives containing membranotropic volumetrical carbocycles in their molecule against SARS-CoV-2 virus ].

Introduction: Currently, low molecular-weight compounds are being developed as potential inhibitors of CoVs replication, targeting various stages of the replication cycle, such as major protease inhibitors and nucleoside analogs. Viroporins can be alternative protein targets. The aim of this study is to identify antiviral properties of histidine derivatives with cage substituents in relation to pandemic strain SARS-CoV-2 in vitro.

A New Approach to the Synthesis of Nanocrystalline Cobalt Boride in the Course of the Thermal Decomposition of Cobalt Complexes [Co(DMF)] with Boron Cluster Anions.

In the course of the study, nanocrystalline cobalt monoboride was prepared by thermal decomposition of precursors [Co(DMF)][An], where [An] = [BH] (), [-BH] () or [BCl] () in an argon atmosphere. Three new salt-like compounds - were prepared when Co(NO) was allowed to react with (EtNH)[An]. Compound is new; the structures of compounds and have been previously reported.

[The first Russian multicenter non-interventional registry study to study the incidence of vitamin D deficiency and insufficiency in Russian Federation].

Aim: To assess the incidence of vitamin D deficiency and insufficiency among the adult population living in the regions of the Russian Federation located at latitudes from 45 to 70.

Materials And Methods: Russian multicenter non-interventional registry study using the "cross-sectional" method.

Results: In this study, 72.

New type of RNA virus replication inhibitor based on decahydro-closo-decaborate anion containing amino acid ester pendant group.

In this work, a synthetic approach to prepare an example of new class of the derivatives of the closo-decaborate anion with amino acids detached from the boron cluster by pendant group has been proposed and implemented. Compound Na[BH-O(CH)C(O)-His-OMe] was isolated and characterized. This compound has an inorganic hydrophobic core which is the 10-vertex boron cage and the -O(CH)C(O)-His-OMe organic substituent.

[Vitamin D deficiency in Russia: the first results of a registered, non-interventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country].

Background: In Russian Federation, there are no large-scale cross-sectional multicenter epidemiological studies assessing the prevalence of vitamin D deficiency and insufficiency in different geographical latitudes. Insufficient solar insolation and inadequate vitamin D content in food dictate the need to study the epidemiological structure of low vitamin D status in Russia.

Aim: To assess the incidence of vitamin D deficiency and insufficiency among the population living in the regions of the Russian Federation located at latitudes from 45 ° to 70 °.

[Assessment of the level of consumption of calcium and vitamin D with food in the adult population of Tyumen Region].

Calcium and vitamin D are essential micronutrients, whose deficiency adversely affects not only bone health, but also the functioning of the whole organism. of this study was to explore the level of calcium and vitamin D intake in the adult population of the Tyumen region, in order to optimize the nutritional program. .

Radical indicator reaction for determination of 1,1-dimethylhydrazine.

2,3,5-Triphenyl-2H-tetrazolium chloride (TPT) has been proposed as a redox indicator for determination of 1,1-dimethylhydrazine (DMH) which is used as a rocket propellant. It has been found that TPT is a sensitive chromogenic reagent due to its potentiometric and spectral characteristics. Products of the reaction between DMH and TPT have been characterized by mass spectrometry and EPR spectroscopy.

Solid-State Reactions of Eicosaborate [B H ] Salts and Complexes.

A series of salts and complexes containing trans- and iso-isomers of octadecahydro-eicosaborate [B H ] dianion is synthesized and characterized using FTIR and B NMR spectroscopies and X-ray diffraction techniques. Both isomers are found to act as four-, bi-, or zero-dentate ligands in reactions with copper(II), silver(I), and lead(II) through apical and/or equatorial boron atoms. Solid-state photo- and thermoinitiated reactions of octadecahydro-eicosaborate isomerization and solvent cleavage occurring in these compounds in a single-crystal-to-single-crystal manner are studied in situ.

Theoretical QTAIM, ELI-D, and Hirshfeld surface analysis of the Cu-(H)B interaction in [Cu2(bipy)2B10H10].

Interaction of [Cu2B10H10] with 2,2'-bipyridine (bipy) afforded a novel binuclear discrete complex of the [Cu2(bipy)2B10H10] composition. Two copper(I) atoms coordinate a bridge boron cage through an apical edge and a triangular BBB face situated at its opposite apical vertices to form four 3c2e (CuHB) and one 2c2e Cu-B bonds. The charge density model was obtained by density functional theory calculations of isolated molecule and crystal.

[Suboccipital tuberculosis: the clinical and radiation and potentialities of current surgical treatment].

The clinical and radiological manifestations of suboccipital tuberculosis have been analyzed in 7 patients aged 7 to 35 years. A case of this condition accompanied by extensive vertebral destruction, abscesses, and basilar impression is described in a 7.5-year-old child.

[Practical objectives of mass immunologic screening of the population].

Techniques for conducting a combination of immunological methods have been elaborated for wide introduction into public health practice. The five main tasks have been substantiated in detail: two are connected with treatment and three with prophylaxis of diseases. These are: (I) prognosis of the course and control of the effectiveness of disease treatment; (2) compiling an immunological passport of people for the improvement of the effective use of the immunogram in clinical practice; (3) detection of genetic and acquired defects of the immune system components; (4) detection of delayed formation and restructuring of the immune system in the process of the organism's age-hormonal reorganization; (5) control of the development of immunological failure (its appearance, course and removal).