Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma.

The sub-ventricular zone (SVZ) is the most well-characterized neurogenic area in the mammalian brain. We previously showed that in 65% of patients with glioblastoma (GBM), the SVZ is a reservoir of cancer stem-like cells that contribute to treatment resistance and the emergence of recurrence. Here, we build a single-nucleus RNA-sequencing-based microenvironment landscape of the tumor mass and the SVZ of 15 patients and two histologically normal SVZ samples as controls.

Efficient Creation of Ultracold Ground State ^{6}Li^{40}K Polar Molecules.

We report the creation of ultracold ground state ^{6}Li^{40}K polar molecules with high efficiency. Starting from weakly bound molecules, stimulated Raman adiabatic passage is adopted to coherently transfer the molecules to their singlet rovibrational ground state |X^{1}Σ^{+},v=0,J=0⟩. By employing a singlet stimulated Raman adiabatic passage pathway and low-phase-noise narrow-linewidth lasers, we observed a one-way transfer efficiency of 96(4)%.

Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma.

The sub-ventricular zone (SVZ) is the most well-characterized neurogenic area in the mammalian brain. We previously showed that in 65% of patients with glioblastoma (GBM), the SVZ is a reservoir of cancer stem-like cells that contribute to treatment resistance and emergence of recurrence. Here, we built a single-nucleus RNA-sequencing-based microenvironment landscape of the tumor mass (T_Mass) and the SVZ (T_SVZ) of 15 GBM patients and 2 histologically normal SVZ (N_SVZ) samples as controls.

Field-programmable-gate-array-based digital frequency stabilization of low-phase-noise diode lasers.

We present the comparison of a field-programmable-gate-array (FPGA) based digital servo module with an analog counterpart for the purpose of laser frequency stabilization to a high-finesse optical cavity. The transfer functions of both the digital and analog modules for proportional-integral-derivative control are measured. For the lasers stabilized to the cavity, we measure the singe-sideband power spectral density of fast phase noise by means of an optical beat with filtered light transmitted through the cavity.

Identification and Characterization of a Novel Microalgal Strain from the Antofagasta Coast AC16-MESO (Chlorophyta) for Biotechnological Applications.

The wide rocky coastline of the Antofagasta hosts an intertidal ecosystem in which the species that inhabit it are routinely exposed to a wide range of physical and chemical conditions and have therefore evolved to tolerate extremes. In the search for new species of potential biotechnological interest with adaptations to a wide range of environmental conditions, the isolation and characterization of microalgae from these ecosystems is of great interest. Here, a new microalgal strain, AC16-MESO, is described, which was isolated from a biofilm collected on the intertidal rocks of the Antofagasta coast (23°36'57.

Identification of a Strain with Algicidal Effects on Red Tide Dinoflagellate in Culture.

The dinoflagellate forms high biomass blooms that discolor the water (red tides), which may pose a serious threat to marine fauna and aquaculture exploitations. In this study, the algicidal effect of a bacterial strain (0YLH) belonging to the genus was identified and evaluated against . The algicidal effects on the dinoflagellate were observed when was exposed to cell-free supernatant (CFS) from stationary-phase cultures of the 0YLH strain.

Assessing the impact of chronic and acute plastic pollution from construction activities and other anthropogenic sources: A case study from the coast of Antofagasta, Chile.

Plastic pollution is a critical environmental issue with far-reaching and not yet fully explored consequences. This study uncovered a significant source of plastic contamination arising from improper application and management of expanded polystyrene (EPS) utilised as expansion joints at a construction site near the coast of Antofagasta, Chile. Through meticulous field observations and calculations, we estimate that a staggering 82.

COVID-19 and the Latinx Community: "Promotoras Represent a Community in Pain".

COVID-19 has disproportionately affected the Latinx community, leading to heightened economic instability and increased mortality/morbidity. Frontline community health workers () have played an integral role in serving low-income Latinx immigrant communities, disseminating health information to this vulnerable community while also facing heightened risks to their own health and wellbeing. This study explores the impact of the pandemic on Latinx communities and the promotoras that serve them, examining how the stresses and inequities the pandemic wrought might be mitigated.

Hemoglobin Denver, a cause of desaturated pulse oximetry. A pediatric case report.

Hemoglobinopathies are genetic disorders that affect the hemoglobin (Hb) molecule. Mutations in the alpha or beta chains altering the Hb tetramer may modify the molecule's oxygen-binding capacity. Hemoglobinopathies with low oxygen affinity may occur with cyanosis and an altered pulse oximetry reading, leading to unnecessary and sometimes invasive tests to rule out cardiovascular and respiratory conditions.

Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24.

Immune checkpoint inhibitors have improved the clinical management of some cancer cases, yet patients still fail to respond to immunotherapy. Dysregulated metabolism is a common feature of many cancers, and metabolites are known to modulate functions in cancer cells. To identify potential metabolic pathways involved in anti-tumor immune response, we employed a metabolic inhibitor-based drug screen in human lung cancer cell lines and examined expression changes in a panel of immune regulator genes.

Medium Definition Liposuction Abdominoplasty.

Unlabelled: Not all patients who exercise regularly and follow a balanced diet will obtain a well-defined abdomen. Medium definition liposuction, together with the removal of abdominal skin, can recreate an adequate connection between the skin/subcutaneous components and the myo-aponeurotic layer, resulting in the perception of muscle definition.

Methods: Over a period of 36 months, 351 patients underwent medium definition liposuction associated with abdominoplasty performed by a single surgeon (G.

Saving a seat at the table for community members: co-creating an attachment-based intervention for low-income Latinx parent-youth dyads using a promotor/a model.

Evidence for the effectiveness of attachment-based interventions in improving youth's socioemotional health increases each year, yet potential for scalability of existing programs is limited. Available programs may have lower acceptability within low-income immigrant communities. Co-designing and implementing interventions with trained community workers (Promotors) offers an appealing solution to multiple challenges, but community workers must have high investment in the program for this to be a workable solution.

Experimental display of the extended polarization coherence theorem.

We report experimental results that show the interplay between visibility, distinguishability, and the degree of polarization, as ruled by a recent extension of the polarization coherence theorem (PCT). Theorems of this kind address duality in both quantum and classical scenarios. We particularly focus on the inherent vector nature of the polarization degree of freedom and display various effects that lie beyond the scope of the original PCT.

"Cotton nail cast": a simple solution for mild and painful lateral and distal nail embedding.

Background: Onychocryptosis is one of the most common painful nail conditions. Conservative treatment may take a long time to obtain effective results.

Objective: The purpose of this study is to show the effectiveness of a conservative treatment of ingrown nails that shows rapid results.

Performance of the international classifications criteria for autoimmune hepatitis diagnosis in Mexican patients.

The revised score of the International Autoimmune Hepatitis Group (R-IAIHG) and the simplified criteria (SC) are used for diagnosis of autoimmune hepatitis (AIH). Our aim is to evaluate the performance of these classifications to differentiate AIH from other autoimmune liver diseases. The frequency of diagnosis of definite AIH was similar both by the R-IAIHG and the SC systems (41% versus 40%), whereas diagnosis of probable AIH was made more commonly by the R-IAIHG than the SC (59% versus 29%), and 23 patients that have been graded as definite (n = 7) or probable (n = 16) AIH by the R-IAIHG had non-diagnostic scores by the SC system.

Evidence for a vacancy-phosphorus-oxygen complex in silicon.

Low-energy (∼0.5 MeV) electrons arising from (60)Co γ-irradiation were used to create phosphorus-vacancy (PV) pairs and oxygen-vacancy pairs in Czochralski-grown Si. Positron annihilation data show that PV pairs anneal in two stages: the commonly observed stage around 125 °C, where one third of the pairs disappear with an activation energy of 0.

[Results of intraventricular resynchronization in patients with severe cardiac failure].

Background: Intraventricular resynchronization with pacemakers is a promising therapy for patients with refractory cardiac failure and intraventricular conductions delay. However its long term effects are not well known.

Aim: To report the results of this therapy in patients with cardiac failure.

[Focal atrial fibrillation. Clinical characteristic and results of radiofrequency ablation].

Background: Atrial fibrillation can originate in arrhythmogenic foci coming from the pulmonary veins. Patients with atrial fibrillation, initiated from triggering foci, can be treated with radiofrequency ablation.

Aim: To report the results of radiofrequency ablation in patients with focal atrial fibrillation.