Efficacy and Safety of PrabotulinumtoxinA for the Treatment of Glabellar Lines in Adult Subjects: Results From 2 Identical Phase III Studies.

Background: PrabotulinumtoxinA is a 900-kDa botulinum toxin Type A produced by Clostridium botulinum.

Objective: To investigate the efficacy and safety of prabotulinumtoxinA for the treatment of glabellar lines.

Materials And Methods: Adult subjects (n = 330 in EV-001; n = 324 in EV-002) with moderate to severe glabellar lines at maximum frown on the 4-point Glabellar Line Scale (GLS; 0 = no lines, 1 = mild, 2 = moderate, and 3 = severe) were enrolled in 1 of 2 identical 150-day, double-blind, placebo-controlled, single-dose, Phase III studies.