Publications by authors named "Ava Dashti"
Aniridia is a rare congenital condition of abnormal eye development arising principally from heterozygous mutation of the PAX6 gene. Among the multiple complications arising in the eye, aniridia-associated keratopathy (AAK) is a severe vision-impairing condition of the cornea associated with a progressive limbal stem cell deficiency that lacks suitable treatment options. Current mouse models of aniridia do not accurately represent the onset and progression dynamics of human AAK, hindering therapy development.
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- Congenital aniridia causes significant vision loss due to the absence of PAX6 protein, leading to related eye issues.
- The study investigates the role of miR-204-5p in regulating PAX6 function, showing that while it effectively suppresses specific gene expressions in lab models, results vary in different cell types.
- In animal models, topical treatment with miR-204-5p did not achieve expected outcomes regarding PAX6 levels or inflammatory gene suppression, indicating the need for more research on long-term effects.