Publications by authors named "Auwalu Garba"
Drug Chem Toxicol
July 2024
Article Synopsis
- - The study aimed to evaluate the side effects of Isometamidium chloride by examining its potential to cause oxidative stress and DNA damage in fruit flies, determining its lethal concentration (LC) and effects on survival, behavior, and gene expression.
- - Results showed that Isometamidium chloride had an LC of 35.88 mg per 10 g of diet and led to a significant decrease in survival rates, climbing ability, and various antioxidant activities over a 28-day period.
- - The drug also caused an increase in oxidative damage markers and reduced the expression of certain protective genes, while molecular docking indicated that it has a strong binding affinity with p53 and PARP1 proteins, suggesting potential cytotoxic effects.
