Publications by authors named "Autumn Grimins"
Coronaviruses are highly transmissible respiratory viruses that cause symptoms ranging from mild congestion to severe respiratory distress. The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has underscored the need for new antivirals with broad-acting mechanisms to combat increasing emergence of new variants. Currently, there are only a few antivirals approved for treatment of SARS-CoV-2.
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- - The 3' untranslated regions (UTRs) of Ebola virus mRNAs are rich in AU sequences, making them targets for RNA binding proteins (ARE-BPs) that regulate RNA stability and translation.
- - Researchers identified potential AU-rich elements (AREs) in EBOV mRNA 3' UTRs and found that these elements can enhance mRNA stability and activity when tested in mammalian and zebrafish models.
- - Coexpressing the Ebola nucleoprotein's (NP) 3' UTR with TTP, an ARE-BP known to destabilize mRNAs, led to reduced gene activity and protein expression, highlighting the role of AU content in regulating Ebola mRNA behavior.