Publications by authors named "Autorino R"
Purpose: To assess the incidence of pelvic insufficiency fractures (PIFs) after concurrent chemoradiotherapy (CCRT) in patients with locally advanced cervical cancer (LACC), their time of onset and risk factors. We also analysed the inter-observer agreement between gynaecologic radiologists (GYN readers) and radiologists expert in musculoskeletal imaging (MSK reader) in detecting PIFs in our tertiary care centre.
Methods: Patients with confirmed LACC who underwent concurrent chemoradiation (CCRT) at our institution from June 2019 to November 2022 were retrospectively included.
Purpose: To compare Italian use with current international guidelines and to evaluate oncological outcomes and toxicity patterns of adjuvant radiation therapy (RT) for endometrial cancer (EC) in Italian women.
Materials And Methods: To conduct a retrospective multicentre Italian study a large database was set up. Inclusion criteria were: accrual between 2010 and 2020, treatment with surgery, post-operative external beam RT (EBRT) and/or interventional radiotherapy (IRT) associated or not with adjuvant chemotherapy.
Article Synopsis
- The study examines the impact of smoking on the outcomes of nonmuscle invasive bladder cancer (NMIBC) treated with BCG instillations, indicating that smokers may have poorer results.
- Approximately 1,313 patients were analyzed using a statistical model to correlate smoking history with disease progression, revealing that heavy smokers have over double the risk of disease progression compared to nonsmokers.
- The results highlight the importance of considering a patient's smoking history in NMIBC management and the necessity for tailored smoking cessation strategies in treatment plans.
Purpose: To evaluate the predictors of delayed discharge for patients undergoing robot-assisted partial nephrectomy (RAPN) at our Institution since the introduction of the single port (SP) robotic system.
Methods: We performed a retrospective review of our prospectively maintained database of patients undergoing RAPN from September 2020 to August 2024. Patients were categorized by the postoperative day of their discharge: POD1 (single overnight stay) or POD > 1 (more than one night stay).
Article Synopsis
- This study aimed to analyze how common surgically induced chronic kidney disease (CKD-S) is in patients with upper tract urothelial carcinoma (UTUC) after they undergo radical nephroureterectomy (RNU), focusing on survival outcomes.* -
- Researchers looked at data from 1,862 patients and found that 34.7% developed CKD-S3a and 39.6% developed CKD-S3b after surgery, with older age, lower preoperative kidney function, and certain chemotherapy treatments linked to higher risks of developing CKD-S3b.* -
- The study revealed that while CKD-S3b patients had worse overall survival rates (59% over 5 years), CK
The advancements of technological devices and software are putting mixed reality in the frontline of teaching medical personnel. The Microsoft HoloLens 2 offers a unique 3D visualization of a hologram in a physical, real environment and allows the urologists to interact with it. This review provides a state-of-the-art analysis of the applications of the HoloLens in a medical and healthcare context of teaching through simulation designed for medical students, nurses, residents especially in urology.
View Article and Find Full Text PDFObjective: To compare surgical parameters and short-term outcomes between open radical cystectomy (ORC) and robotic radical cystectomy with total intracorporeal urinary diversion (icRARC).
Methods: Among the study period, 133 patients who underwent ORC and pelvic node dissection for bladder cancer (group 1) were matched and compared to 61 patients who underwent icRARC during the same period (group 2). The groups were matched 1:1 according to their propensity scores adjusted on their baseline demographics and disease characteristics.
Article Synopsis
- About 70% of bladder cancer cases are non-muscle invasive (NMIBC) and inflammation, influenced by factors like smoking, affects treatment outcomes with BCG therapy.
- A study analyzed data from 1,313 NMIBC patients to examine how smoking and systemic inflammation impact the effectiveness of BCG using a machine-learning algorithm.
- The results indicated that both smoking status and specific inflammatory markers can significantly predict the risk of disease progression, highlighting the need for tailored treatment strategies and further research to confirm the findings.
Robotic-assisted surgery for the treatment of urologic cancers: recent advances.
Expert Rev Med Devices
December 2024
Introduction: Recent advancements in single-port surgery, robotic platforms, 3D models and artificial intelligence have transformed surgical procedures, especially in urology. These innovations enhance precision, safety, and efficacy, reducing invasiveness and recovery times. The review focuses on the latest in robotic-assisted surgery for genitourinary cancers, highlighting the shift toward personalized, minimally invasive treatments.
View Article and Find Full Text PDFObjective: To highlight the role of hyper accuracy three-dimensional (3D) reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy (RAPN).
Methods: A transperitoneal RAPN was performed in a 62-year-old male patient presenting with a 4 cm right anterior interpolar renal mass (R.E.
Article Synopsis
- Socioeconomic determinants of health (SDOH) are often overlooked in assessing risks for urological surgeries, which may lead to disparities in patient outcomes, particularly after minimally invasive radical prostatectomy (MIRP).
- A study using data from over 100,000 patients revealed that about 6% reported SDOH, which were linked to a 24% increased risk of complications post-surgery, including higher rates of urinary tract infections and acute kidney injuries.
- The findings highlight the need for healthcare systems to address SDOH to improve patient outcomes and reduce complications after procedures like MIRP.
Article Synopsis
- Minimally invasive surgery offers shorter hospital stays, enabling the potential for outpatient (OP) procedures, especially with the introduction of single-port (SP) robotic techniques in urology.
- A literature review analyzed the safety and feasibility of OP robotic urological surgeries, revealing high same-day discharge rates and lower complication risks compared to inpatient procedures.
- Overall, the study concludes that outpatient robotic urological surgery is both feasible and safe for selected patients, with SP-RARP procedures showing even better outcomes than multiport options.
Article Synopsis
- * The survey had a 28.6% completion rate with 201 responses, revealing that while about half of the institutions using SP platforms have done so for over 2 years, structured training is limited, leading to concerns about hands-on experience and the learning curve associated with SP procedures.
- * Despite recognizing the clinical benefits of SP surgery, many trainees do not view proficiency in it as essential for career advancement; however, predictors of future SP implementation include academic aspirations and the availability of SP platforms
Article Synopsis
- The study investigates the effects of neoadjuvant and adjuvant chemotherapy on survival rates in patients with Upper tract urothelial carcinoma undergoing Nephroureterectomy, using data from a multicenter registry.
- A total of 1,994 patients were analyzed, revealing that neoadjuvant chemotherapy notably improved cancer-specific and overall survival, especially in patients with advanced tumors or positive nodes.
- The results suggest a significant survival benefit from neoadjuvant chemotherapy, indicating a need for further research to explore its impact in this patient population.
Article Synopsis
- Penile cancer is a rare type of cancer that affects the penis, with an estimated 2,100 new cases and 500 deaths in the U.S. in 2024.
- Surgery has traditionally been used as the main treatment, but new studies suggest that less invasive options may work just as well without requiring major surgeries.
- It's really important to help patients cope with the emotional effects of the disease, as losing part of the penis can impact their mental health and quality of life, so therapies and support are key.
Importance: Evidence on prostate cancer (PCa) in transgender women is very limited; data are needed to reduce gender disparities in both PCa knowledge and health care.
Objective: To evaluate the prevalence of PCa among transgender women in the US and assess the factors associated with PCa, and factors associated with biochemical recurrence (BCR) and bone metastases (BM) secondary to PCa in the transgender population.
Design, Setting, And Participants: A retrospective cohort study was conducted in October 2023, covering the period between 2011 and 2022 (12-year analysis).
Article Synopsis
- A study analyzed data from over 65,000 patients who underwent either open partial nephrectomy (OPN) or minimally invasive partial nephrectomy (MIPN) between 2011 and 2021, using a comprehensive insurance claims database.
- The findings showed a decrease in OPN usage and an increase in MIPN, with 15% of OPN patients experiencing complications compared to 9% for MIPN patients.
- Social determinants of health (SDOH) significantly influenced postoperative outcomes, with both surgical approaches showing higher complication risks linked to SDOH, but OPN demonstrated a notably higher risk overall.
Survival Outcomes by Race Following Surgical Treatment for Upper Tract Urothelial Carcinoma.
Clin Genitourin Cancer
December 2024
Objective: Discrepancies in survival outcomes of various genitourinary tract malignancies have been documented across different racial and ethnic groups. Here we sought to examine long-term survival outcomes of patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU) when stratified by race.
Methods: A multicenter retrospective analysis using the ROBUUST (ROBotic surgery for Upper tract Urothelial cancer Study) registry identified patients undergoing RNU for UTUC between 2015 and 2022 at 12 centers across the United States, Europe, and Asia.
The single port robotic surgical "toolbox": a primer for beginners.
Minerva Urol Nephrol
October 2024
Background: The aim of this study is to provide a comprehensive overview of the da Vinci Single Port robotic platform, including instruments and tools that can aid in implementing the use of this novel platform.
Methods: Footage recorded during various Single port robotic urologic procedures and dry labs performed at two US institutions was used as video material. A step-by-step guide illustrating key points on OR set-up, platform, instruments, trocar configurations, intraoperative suctioning, bedside assistance were discussed and highlighted.
Article Synopsis
- This study looked at urinary incontinence (UI) in patients who had surgery for a prostate condition called BPH.
- Out of over 274,000 patients treated, about 11,000 had ongoing UI a year after their surgery.
- Some types of surgeries had higher chances of causing UI, like HoLEP and PVP, while others like Prostatic Artery Embolization had much lower rates of this problem.
Background: Single-port robot-assisted simple prostatectomy is a minimally invasive alternative for patients with large benign prostatic hyperplasia with severe symptoms and/or failure of medical treatment. In recent literature, the rate of incidental prostate cancer after simple prostatectomy ranges from 1.8% to 13.
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