Publications by authors named "Austyn Trull"
Article Synopsis
- There's a growing availability of public biological data, necessitating guidelines for effective use and downloading.
- The 10 rules for using this data cover aspects like purposeful research, evaluating data, checking reuse requirements, and ensuring ethical practices.
- Following these guidelines aims to enhance data reuse and reproducibility in research by making data and tools more accessible and shareable.
To discover driver fusions beyond canonical exon-to-exon chimeric transcripts, we develop CICERO, a local assembly-based algorithm that integrates RNA-seq read support with extensive annotation for candidate ranking. CICERO outperforms commonly used methods, achieving a 95% detection rate for 184 independently validated driver fusions including internal tandem duplications and other non-canonical events in 170 pediatric cancer transcriptomes. Re-analysis of TCGA glioblastoma RNA-seq unveils previously unreported kinase fusions (KLHL7-BRAF) and a 13% prevalence of EGFR C-terminal truncation.
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