Publications by authors named "Austin P Runde"
Lymphoid-primed multipotent progenitor (LMPP)-like and granulocyte-monocyte progenitor (GMP)-like leukemia stem cells (LSCs) co-exist in the blood of most patients with acute myeloid leukemia (AML). Complete elimination of both types of LSCs is required to cure AML. Using an MLL-AF9-induced murine AML model, we studied the role of hematopoietic cytokines in the survival of LMPP- and GMP-like LSCs.
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- TBK1 is an important kinase in regulating inflammation and innate immunity, activated by pathogens and mutated oncogenes like K-RAS/N-RAS.
- Although TBK1 mutations aren't found in human cancers, its abnormal activation is linked to various cancers, suggesting it as a potential treatment target.
- Current research on TBK1 focuses on its role in cancer development and therapy, with some inhibitors tested, notably momelotinib, indicating promising avenues for future cancer treatments.