Higher medication complexity in persons with HIV is associated with lower tenofovir diphosphate in dried blood spots.

Study Objective: To assess the association between tenofovir diphosphate (TFV-DP) in dried blood spots (DBS), a measure of cumulative tenofovir-based antiretroviral (ART) adherence, with medication regimen complexity in persons with human immunodeficiency virus (PWH).

Design: Prospective clinical cohort (up to three visits over 48 weeks).

Setting: Academic-based HIV clinic.