Publications by authors named "Austin K Murchison"
Article Synopsis
- BamA is a crucial part of the β-barrel assembly machine (BAM) that helps insert proteins into the outer membrane of Gram-negative bacteria like E. coli.
- Researchers used in vitro selection techniques to find peptide macrocycles that can disrupt BamA's function by binding to different conformational states, specifically Peptide Targeting BamA-1 (PTB1) and Peptide Targeting BamA-2 (PTB2).
- These findings are important for developing new antibiotics targeting BamA and could also be applied to discover modulators for other similar proteins in the future.
Sharing is caring: TMEM165 a Golgi calcium importer used by the lysosome.
Trends Biochem Sci
August 2024
Calcium is a crucial second messenger in the cell that is stored in organelles including lysosomes. Proteins that facilitate calcium entry to the lysosome were unknown. A recent report by Zajac et al.
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