A Narrative Medicine Pilot Curriculum for Internal Medicine Residents.

Narrative medicine (NM) is the practice of reflecting on patient stories, which can improve physician empathy and has been linked to higher levels of well-being. We implemented a NM curriculum for a large internal medicine residency program and report the curriculum's positive effects.

Long-term outcomes of intrathecal baclofen in ambulatory multiple sclerosis patients: A single-center experience.

Background: Intrathecal baclofen (ITB) is traditionally reserved for non-ambulatory patients.

Objective: To investigate outcomes of ITB in ambulatory multiple sclerosis (MS) patients.

Methods: Changes in outcome measures were estimated by a mixed effect model, while the complication rate was calculated using a logistic regression.

REV-ERBα ameliorates heart failure through transcription repression.

A cure for heart failure remains a major unmet clinical need, and current therapies targeting neurohomonal and hemodynamic regulation have limited efficacy. The pathological remodeling of the myocardium has been associated with a stereotypical gene expression program, which had long been viewed as the consequence and not the driver of the disease until very recently. Despite the advance, there is no therapy available to reverse the already committed gene program.