Publications by authors named "Austin D E Swafford"
Article Synopsis
- - The study introduced new electrochemiluminescence (ECL) assays to detect insulin autoantibodies (IAA) and anti-insulin antibodies (IA), aiming to overcome the challenges of the traditional 125I-insulin radiobinding assay, which is inefficient and inconsistent across labs.
- - In tests using NOD mice and human samples, the ECL assays demonstrated quick results and high accuracy, effectively correlating IAA levels with diabetes onset and providing reliable measurements across different laboratories.
- - The researchers concluded that these innovative ECL assays could improve standardization and speed in detecting insulin antibodies, with plans to further evaluate the human IA assay in at-risk populations for type 1 diabetes.
Objective: IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association (GWA) studies have linked a region of the 3'-UTR of IKZF1 with C-ALL susceptibility, we tested whether IKZF1 is associated with the autoimmune disease type 1 diabetes.
Research Design And Methods: rs10272724 (T>C) near IKZF1 at 7p12 was genotyped in 8,333 individuals with type 1 diabetes, 9,947 control subjects, and 3,997 families of European ancestry.
Article Synopsis
- Single-walled carbon nanotubes (CNTs) can absorb near-infrared (NIR) light and emit heat, making them potential agents for tumor ablation when targeted specifically to cancer cells.!* -
- The study demonstrated that CNTs can be coupled with antibodies that specifically bind to tumor cells, allowing for targeted delivery and destruction of these cells when exposed to NIR light.!* -
- Biocompatible CNT dispersions were created using biotinylated polar lipids, and the experiment showed that only tumor cells with the specific antibody-bound CNTs were eliminated by the NIR exposure, highlighting the method's precision in targeting cancer cells without harming surrounding tissue.!*