Daily Effects of Challenge and Hindrance Stressors on Work-to-Family Spillover: The Moderating Effects of Engaging in Workaholic Behaviors.

This study seeks to investigate the effects of challenge and hindrance stressors, and the moderating role of workaholic behaviors in predicting work-to-family positive and negative spillover. Non-instructional personnel at a public university completed measures of stressors and workaholic behaviors during the workday and work-to-family spillover before going to bed over a period of five weekdays (Level-1  = 386; Level-2  = 106). Results from multilevel regression indicated that challenge stressors exhibited no relationship with work-to-family positive or negative spillover, while hindrance stressors were positively related to negative work-to-family spillover.

Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue.

Brain arteriovenous malformation (BAVM), a rare but important cause of intracranial hemorrhage, has increased angiogenesis and inflammation as key components of the nidus of abnormal vessels and stroma that form the resected surgical specimen. Accordingly, both vascular endothelial growth factor (VEGF) and transforming growth factor-β have been implicated in the pathology of BAVM for their proangiogenic and vascular-regulating roles. The C-terminal fragment of the extracellular matrix component perlecan (domain V, DV) has been shown to be increased and through the α5β1 integrin, to increase VEGF levels in and around areas of cerebral ischemic injury, another proangiogenic condition.