Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study.

Curcumin (CUR), a polyphenolic compound, shows promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta potential of -15 mV were prepared.

Optimization of Image Quality and Organ Absorbed Dose for Pediatric Chest X-Ray Examination: In-House Developed Chest Phantom Study.

Purpose: This study aimed to identify proper exposure techniques to maintain optimal diagnostic image quality with minimum radiation dose for anteroposterior chest X-ray projection in pediatric patients.

Methods: Briefly, an in-house developed pediatric chest phantom was constructed. Next, nanodot OSLDs were used for organ absorbed dose measurement and placed in the lung area, and the phantom was exposed to various exposure techniques (ranging from 50 to 70 kVp with 1.

Fabrication and Characterization of Human Serum Albumin Particles Loaded with Non-Sericin Extract Obtained from Silk Cocoon as a Carrier System for Hydrophobic Substances.

Non-sericin (NS) extract was produced from the ethanolic extract of silk cocoons. This extract is composed of both carotenoids and flavonoids. Many of these compounds are composed of substances of poor aqueous solubility.

Doxorubicin-Loaded Human Serum Albumin Submicron Particles: Preparation, Characterization and In Vitro Cellular Uptake.

Doxorubicin (DOX) is an effective anthracycline antibiotic drug which is commonly used in a broad range cancer therapy. However, due to dose depending side effects and toxicity to non-cancerous tissues, its clinical applications are restricted. To overcome these limitations, human serum albumin (HSA) has been investigated as a biocompatible drug delivery vehicle.

Albumin Submicron Particles with Entrapped Riboflavin-Fabrication and Characterization.

Although riboflavin (RF) belongs to the water-soluble vitamins of group B, its solubility is low. Therefore, the application of micro-formulations may help to overcome this limiting factor for the delivery of RF. In this study we immobilized RF in newly developed albumin submicron particles prepared using the Co-precipitation Crosslinking Dissolution technique (CCD-technique) of manganese chloride and sodium carbonate in the presence of human serum albumin (HSA) and RF.

In-vitro haemocompatibility of dextran-protein submicron particles.

Blood compatibility is a key requirement to fulfil for intravenous administration of drug and oxygen carrier system. Recently, we published the fabrication of oxidised-dextran (Odex)-crosslinked protein particles by one-pot formulation. In the current study we investigate the haemocompatibility of these Odex - particles including albumin particles (Odex-APs) and haemoglobin particles (Odex-HbMPs).

Antioxidative protection of haemoglobin microparticles (HbMPs) by PolyDopamine.

Clinically applicable haemoglobin-based oxygen carriers (HBOCs) should neither induce immunological nor toxic reactions. Additionally, Hb should be protected against oxidation. In the absence of protective enzymes (superoxide dismutase (SOD) and catalase (CAT)) Hb is oxidized to MetHb and thus losing its function of oxygen delivery.

Improved oxygen storage capacity of haemoglobin submicron particles by one-pot formulation.

The coprecipitation-cross-linking-dissolution (CCD) technique for protein submicron particle fabrication was improved by omitting one preparation step using the macromolecular cross-linker, periodate-oxidized dextran (Odex, M.W. of 40 and 70 kDa).

Simulation and experimental studies on magnetic hyperthermia with use of superparamagnetic iron oxide nanoparticles.

Our purpose of this study was to present simulation and experimental studies on magnetic hyperthermia (MH) with use of an alternating magnetic field (AMF) and superparamagnetic iron oxide nanoparticles (Resovist®). In the simulation studies, the energy dissipation (P) and temperature rise rate (∆T/∆t) were computed under various conditions by use of the probability density function of the particle size distribution based on a log-normal distribution. P and ∆T/∆t and their dependence on the frequency of the AMF (f) largely depended on the particle size of Resovist®.