Publications by authors named "Aurore Vuidel"
Article Synopsis
- Phelan-McDermid syndrome (PMDS) is caused by problems with a gene called SHANK3, which is found on chromosome 22 and is linked to autism.
- Researchers studied patients with PMDS and found that not having enough SHANK3 causes brain cells to change too much, make more connections, and not work as well.
- They tested thousands of small drugs and found one called Benproperine that can help fix some of these problems when given at the right time during brain cell growth.
PLK1 is an important regulator of mitosis whose protein levels and activity fluctuate during the cell cycle. PLK1 dynamically localizes to various mitotic structures to regulate chromosome segregation. However, the signaling pathways linking localized PLK1 activity to its protein stability remain elusive.
View Article and Find Full Text PDFCombining multiple Parkinson's disease (PD) relevant cellular phenotypes might increase the accuracy of midbrain dopaminergic neuron (mDAN) in vitro models. We differentiated patient-derived induced pluripotent stem cells (iPSCs) with a LRRK2 G2019S mutation, isogenic control, and genetically unrelated iPSCs into mDANs. Using automated fluorescence microscopy in 384-well-plate format, we identified elevated levels of α-synuclein (αSyn) and serine 129 phosphorylation, reduced dendritic complexity, and mitochondrial dysfunction.
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