Publications by authors named "Aurore Lomet"
Front Immunol
August 2023
Article Synopsis
- * Researchers used predictive tools to create a heatmap identifying which amino acid changes could lower the binding affinity of the antibody's peptides to HLA II molecules without affecting the antibody's ability to target its specific antigen.
- * By applying this method to adalimumab, an antibody used for treating inflammatory conditions, the study produced 200 variants with reduced HLA binding scores and identified three that had improved affinity and neutralization capabilities compared to the original adalimumab.
