Decreasing patient-reported burden of treatment: A systematic review of quantitative interventional studies.

Objectives: To describe and analyse studies aiming at quantitatively assessing the impact of interventions on patient-reported burden of treatment as an outcome (primary or secondary).

Methods: The aim of the search strategy was to identify all publications describing a medical intervention intended to reduce patient-reported burden of treatment in adult patients with long-term conditions, from January 1, 2008 to July 15, 2019. Four databases (Medline, PsycINFO, the "Trials" section of the Cochrane-Library, and OpenGrey) were searched in English, French, Spanish, Italian and Portuguese.