Significant decrease in interval colorectal cancer incidence after implementing immunochemical testing in a multiple-round guaiac-based screening programme.

Background And Aims: We aimed to evaluate the effects of switching to faecal immunochemical testing (FIT) on the cumulative 2-year incidence rate of interval cancers, interval cancer rate and test sensitivity within a mature population-based colorectal cancer screening programme consisting of six rounds of biennial guaiac faecal occult blood testing (gFOBT).

Methods: The FIT results were compared with those of gFOBT used in each of the previous two rounds. For the three rounds analysed, 279,041 tests were performed by 156,186 individuals.

Solitary rectal ulcer syndrome in 102 patients: Do different phenotypes make sense?

Background: Little is known about the pathophysiological mechanisms of solitary rectal ulcer syndrome (SRUS).

Aims: We aim to identify the different phenotypes, taking into account complaints, anatomy and anorectal physiology.

Methods: Complaints, endoscopy results, and physiology data of patients with histologically proven SRUS were collected and analysed.

Improving the screening of precancerous anal lesions in high-risk subjects with normal cytology: A longitudinal cohort study using simple tests.

Unlabelled: For patients at high risk of anal cancer, annual screening strategies using invasive evaluation methods are stressful. According to a normal examination at baseline using simple and non invasive tests, the aim of the work was to quantify neoplastic events.

Patients And Method: Data from patients with a normal evaluation at the first visit were retrospectively extracted from a prospective database.