Publications by authors named "Aurora Gomez-Vecino"

Article Synopsis
  • Cardiotoxicity due to anthracyclines (CDA) is a major concern for cancer patients, but predicting who will develop this complication remains challenging due to its complex genetic basis.
  • Researchers conducted a study using genetically diverse mice treated with doxorubicin and docetaxel to explore the link between intermediate molecular phenotypes (IMPs) in the heart and CDA susceptibility, identifying quantitative trait loci (QTLs) associated with these traits.
  • The study revealed that specific genetic variants related to IMPs could serve as markers for CDA risk in patients, which may help tailor more personalized treatment strategies for those receiving cancer therapies like anthracyclines.
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Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex disease whose polygenic component is mainly unidentified. We propose that levels of intermediate molecular phenotypes in the myocardium associated with histopathological damage could explain CDA susceptibility; so that variants of genes encoding these intermediate molecular phenotypes could identify patients susceptible to this complication.

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Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. These changes are not specific to tumors but also take place during the physiological growth of tissues. Indeed, the cellular and tissue mechanisms present in the tumor have their physiological counterpart in the repair of tissue lesions and wound healing.

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Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of these metabolic changes are located in the tumor parenchymal cells, where oncogenic mutations induce an imperative need to proliferate and cause tumor initiation and progression. Cancer cells undergo significant metabolic reorganization during disease progression that is tailored to their energy demands and fluctuating environmental conditions.

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The data presented in this article are related to the research paper entitled "The biological age linked to oxidative stress modifies breast cancer aggressiveness" (M.M. Sáez-Freire, A.

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The incidence of breast cancer increases with age until menopause, and breast cancer is more aggressive in younger women. The existence of epidemiological links between breast cancer and aging indicates that both processes share some common mechanisms of development. Oxidative stress is associated with both cancer susceptibility and aging.

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