Publications by authors named "Auromira Khuntia"

Cancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics and therapeutic agents, cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis in cancer patients. Therefore, tremendous efforts have been expended to address this significant clinical issue and improve therapeutic efficacy.

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Article Synopsis
  • Triple negative breast cancer (TNBC) is highly aggressive and resistant to treatment, largely due to cancer stem cells (CSCs) that conventional therapies fail to target, necessitating new strategies for effective treatment.
  • * This research focuses on the elevated glycolytic metabolism in breast CSCs, aiming to exploit their metabolic vulnerabilities to enhance TNBC treatment.
  • * By using a new form of the drug piperlongumine (PL) delivered through nanoparticles (PL-NPs), the study showed that this method effectively inhibits glycolysis in CSCs and leads to significant tumor regression in preclinical models.
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Cancer remains the leading cause of death and rapidly evolving disease worldwide. The understanding of disease pathophysiology has improved through advanced research investigation, and several therapeutic strategies are being used for better cancer treatment. However, the increase in cancer relapse and metastatic-related deaths indicate that available therapies and clinically approved chemotherapy drugs are not sufficient to combat cancer.

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The outbreak of SARS-CoV-2 infection has presented the world with an urgent demand for advanced diagnostics and therapeutics to prevent, treat and control the spread of infection. Nanotechnology seems to be highly relevant in this emergency due to the unique physicochemical properties of nanomaterials which offer versatile chemical functionalization to create advanced biomedical tools. Here, nano-intervention is discussed for designing effective strategies in developing advanced personal protective equipment kits, disinfectants, rapid and cost-effective diagnostics and therapeutics against the infection.

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