Semi-Interpenetrating Polymer Networks Based on Hydroxy-Ethyl Methacrylate and Poly(4-vinylpyridine)/Polybetaines, as Supports for Sorption and Release of Tetracycline.

Semi-interpenetrating polymer networks (semi-IPN) represent a type of polymeric material that has gained increasing amount of interest for their potential biomedical application. This study presents the synthesis, characterization and tetracycline loading/release capacities of semi-IPNs based on hydroxyethyl methacrylate (HEMA) and poly(4-vinylpyridine) (P4VP) or poly (1-vinyl-4-(1-carboxymethyl) pyridinium betaine) (P4VPB-1) and poly (1-vinyl-4-(2-carboxyethyl) pyridinium betaine) (P4VPB-2). The optimization of the semi-IPNs synthesis was achieved by studying the influence of reaction parameters (chemical structure of the cross-linking agent, HEMA:crosslinker ratio, HEMA:linear polymers ratio and the type of solvent of the linear polymers) on the yield of obtaining semi-IPNs and swelling capacity of these systems.

Grafted Microparticles Based on Glycidyl Methacrylate, Hydroxyethyl Methacrylate and Sodium Hyaluronate: Synthesis, Characterization, Adsorption and Release Studies of Metronidazole.

Three types of precursor microparticles based on glycidyl methacrylate, hydroxyethyl methacrylate and one of the following three crosslinking agents (mono-, di- or triethylene glycol dimethacrylate) were prepared using the suspension polymerization technique. The precursor microparticles were subsequently used to obtain three types of hybrid microparticles. Their synthesis took place by grafting sodium hyaluronate, in a basic medium, to the epoxy groups located on the surface of the precursor microparticles.