Publications by authors named "Aurelio Perez-Favila"
Gene variants rs5182, rs2074192, and rs4343 in the renin-angiotensin-aldosterone system are associated with symptom severity, higher odds of hospitalization, and death in COVID-19.
Int J Infect Dis
July 2024
Article Synopsis
- The study aimed to investigate how certain gene variants in the renin-angiotensin-aldosterone system relate to the severity and outcomes of COVID-19.
- A total of 104 patients were analyzed, comparing 34 asymptomatic individuals with 70 symptomatic patients, focusing on specific gene variants through genotyping tests.
- Results showed that the T/T genotype of AGTR1 rs5182 was linked to a higher likelihood of severe symptoms and hospitalization, while a specific haplotype (CTG) was associated with a significantly reduced risk of death from COVID-19.
Article Synopsis
- The study investigates how certain gene variants influence the severity of COVID-19 symptoms and outcomes in patients infected with SARS-CoV-2.
- It analyzes a cohort of 104 patients, distinguishing between asymptomatic and symptomatic cases, while focusing on specific gene variants linked to the immune response.
- Results suggest that individuals carrying specific gene alleles (C allele of rs1293767 and T allele of rs2285932) are less likely to experience symptomatic COVID-19, indicating a potential genetic protective effect and highlighting the variants as possible markers for disease severity.
Antifibrotic Drugs against Idiopathic Pulmonary Fibrosis and Pulmonary Fibrosis Induced by COVID-19: Therapeutic Approaches and Potential Diagnostic Biomarkers.
Int J Mol Sci
January 2024
The COVID-19 pandemic has had a significant impact on the health and economy of the global population. Even after recovery from the disease, post-COVID-19 symptoms, such as pulmonary fibrosis, continue to be a concern. This narrative review aims to address pulmonary fibrosis (PF) from various perspectives, including the fibrotic mechanisms involved in idiopathic and COVID-19-induced pulmonary fibrosis.
View Article and Find Full Text PDFDiabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus, with more than 400 million people diagnosed globally, and the condition is responsible for lower extremity amputation in 85% of people affected, leading to high-cost hospital care and increased mortality risk. Neuropathy and peripheral arterial disease trigger deformities or trauma, and aggravating factors such as infection and edema are the etiological factors for the development of DFUs. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk.
View Article and Find Full Text PDFDiabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to serious physical consequences like amputations of limbs and equally severe social, psychological, and economic outcomes. It is reported that up to 25% of patients with diabetes develop a DFU in their lifetime, and more than half of them become infected. Therefore, it is essential to manage infection and ulcer recovery to prevent negatives outcomes.
View Article and Find Full Text PDFBackground: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia.
Objective: The objective of this study is to evaluate the usefulness of nine urinary metalloproteinases to predict the risk of preeclampsia development.