Publications by authors named "Aurelie Tatopoulos"
Article Synopsis
- A study examined the prevalence and incidence of interstitial lung disease in children (chILD) in France, finding it affects 44 children per million in 2022 and has an incidence of 4.4 per million.
- The research included data from 790 patients across 42 centers, noting that the median age for diagnosis was 3 months, with a significant portion having familial forms.
- Management typically involved oxygen therapy and corticosteroids, with survival rates being 57.3% for children diagnosed before 2 years and 86% for those diagnosed between 2 and 18 years; the study highlights the need for improved international data collection and standardized practices.
Article Synopsis
- Cutis laxa (CL) is a rare connective tissue disorder with symptoms like wrinkled and sagging skin, and it can sometimes affect other body systems.
- This report focuses on a 17-month-old girl diagnosed with autosomal recessive type 1C cutis laxa (ARCL1C), highlighting a new genetic mutation in the LTBP4 gene that is linked to her condition.
- The study involved genetic testing to explore the effects of a specific nine-base pair deletion in the LTBP4 gene, suggesting its role in causing cutis laxa in this patient.
Lung clearance index (LCI) is a biomarker of ventilation inhomogeneity. Data are scarce on its usefulness in daily practice for monitoring the effects of treatments in older children and adults with CF. In this French observational study of lumacaftor-ivacaftor, 63 of 845 patients (7.
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- Interstitial lung disease in children (chILD) is a severe and varied condition that negatively impacts the quality of life (QoL) for affected kids due to ongoing treatment needs and hospital visits.* -
- The study involved 78 children who filled out a QoL assessment, revealing that children with chILD reported significantly lower QoL scores compared to healthy peers.* -
- Identifiable factors such as disease severity, oxygen therapy, and nutritional support contribute to a lower QoL, which can help healthcare providers spot at-risk children.*
Deep inspiration (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation. The hypothesis was tested that DI induces more relaxation in methacholine induced bronchoconstriction-solely determined by the smooth muscle contraction-than in exercise induced bronchoconstriction, which is contributed to by both smooth muscle contraction and airway wall inflammation.
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