Publications by authors named "Aurelia Errante"
CD98hc (SLC3A2) is the heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells. Overexpression of CD98hc occurs widely in cancer cells and is associated with poor prognosis clinically, but its exact contributions to tumorigenesis are uncertain. In this study, we showed that genetic deficiency of CD98hc protects against Ras-driven skin carcinogenesis.
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- Skin aging is connected to decreased cell growth and breakdown of the extracellular matrix, with CD98hc playing a role in integrin signaling.
- Researchers found that removing CD98hc in skin does not hinder cell adhesion but leads to poor skin health and healing, mimicking signs of aging.
- The study identifies a critical pathway involving CD98hc, integrins, and RhoA that regulates skin homeostasis, with disrupted RhoA activation linked to faulty amino acid transport in the absence of CD98hc.