Magnetic Hyperthermia in Glioblastoma Multiforme Treatment.

Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At a worldwide level, new therapeutic methods are continuously being researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 years as a solution used as a single therapy or combined with others for glioma tumor assessment in preclinical and clinical studies.

Polysaccharide Composite Alginate-Pectin Hydrogels as a Basis for Developing Wound Healing Materials.

This article presents materials that highlight the bioengineering potential of polymeric systems of natural origin based on biodegradable polysaccharides, with applications in creating modern products for localized wound healing. Exploring the unique biological and physicochemical properties of polysaccharides offers a promising avenue for the atraumatic, controlled restoration of damaged tissues in extensive wounds. The study focused on alginate, pectin, and a hydrogel composed of their mixture in a 1:1 ratio.

Improving the Hydrophobicity of Plasticized Polyvinyl Chloride for Use in an Endotracheal Tube.

An endotracheal tube (ETT) is a greatly appreciated medical device at the global level with widespread application in the treatment of respiratory diseases, such as bronchitis and asthma, and in general anesthesia, to provide narcotic gases. Since an important quantitative request for cuffed ETTs was recorded during the COVID-19 pandemic, concerns about infection have risen. The plasticized polyvinyl chloride (PVC) material used to manufacture ETTs favors the attachment of microorganisms from the human biological environment and the migration of plasticizer from the polymer that feeds the microorganisms and promotes the growth of biofilms.

Successful management of chronic migraine through manual therapy. A case report.

Migraine is the second most debilitating condition affecting a significant portion of the general population, particularly young adults under 50. Despite extensive research, the etiology of migraine remains diverse and often multifactorial, with limited clarity on the specific underlying pathogenic processes. Consequently, the treatment of migraine lacks a mechanism-based approach.

The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders.

This comprehensive review article dives deep into the Golgi apparatus, an essential organelle in cellular biology. Beginning with its discovery during the 19th century until today's recognition as an important contributor to cell function. We explore its unique organization and structure as well as its roles in protein processing, sorting, and lipid biogenesis, which play key roles in maintaining homeostasis in cellular biology.

Antimicrobial Solutions for Endotracheal Tubes in Prevention of Ventilator-Associated Pneumonia.

Ventilator-associated pneumonia is one of the most frequently encountered hospital infections and is an essential issue in the healthcare field. It is usually linked to a high mortality rate and prolonged hospitalization time. There is a lack of treatment, so alternative solutions must be continuously sought.

The Brain's Glymphatic System: Drawing New Perspectives in Neuroscience.

This paper delves into the intricate structure and functionality of the brain's glymphatic system, bringing forth new dimensions in its neuroscientific understanding. This paper commences by exploring the cerebrospinal fluid (CSF)-its localization, production, and pivotal role within the central nervous system, acting as a cushion and vehicle for nutrient distribution and waste elimination. We then transition into an in-depth study of the morphophysiological aspects of the glymphatic system, a recent discovery revolutionizing the perception of waste clearance from the brain, highlighting its lymphatic-like characteristics and remarkable operations.

Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer's, Parkinson's, and Huntington's Diseases and Amyotrophic Lateral Sclerosis.

Neurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon, and the change in the perspective regarding gene editing and the advantages of this action. The aim of this paper is to analyze the newest approaches in genetics and molecular sciences regarding four of the most important neurodegenerative disorders: Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.

Intracranial arteriovenous malformation (AVM) or meningothelial meningioma (MM)? Outlining the similarities and differences on imaging studies for an accurate diagnosis, case report.

Introduction And Importance: AVM and MM represent neurosurgical challenges, not only when involving eloquent brain, but also by posing a significant intraoperative haemorrhagic risk. It is a challenge in itself to establish a proper differential diagnosis between the two lesions, especially since they require distinct interventional plan of action. We present the case of a patient initially diagnosed by specialists with an intracranial AVM, which was revealed intraoperatively to be in fact an MM.

A Prospective Viewpoint on Neurological Diseases and Their Biomarkers.

Neurodegenerative diseases (NDDs) are disorders that affect both the central and peripheral nervous systems. To name a few causes, NDDs can be caused by ischemia, oxidative and endoplasmic reticulum (ER) cell stress, inflammation, abnormal protein deposition in neural tissue, autoimmune-mediated neuron loss, and viral or prion infections. These conditions include Alzheimer's disease (AD), Lewy body dementia (LBD), and Parkinson's disease (PD).

Cranioplasty after Two Giant Intraosseous Angiolipomas of the Cranium: Case Report and Literature Review.

Angiolipomas are rare, benign tumors resulting from the proliferation of adipose tissue and blood vessels, most frequently encountered subcutaneously at the upper limbs and trunk level. Due to their rarity, few cases of intraosseous angiolipomas are presented in the literature. The paper reports a 50-year-old female case with intracranial hypertension syndrome, frontal and parietal headache, nausea, and vomiting symptoms increasing in intensity.

SARS-COV-2 - the pandemic of the XXI century, clinical manifestations - neurological implications.

In December 2019, in Wuhan, China, the first cases of infection with SARS-CoV 2 responsible for COVID-19 disease were identified. SARS-CoV 2 was declared a pandemic on March 11, 2020, and since then has attracted the medical world's attention. The threat to humans' health that this emerging pandemic could leave raises awareness on the importance of understanding the mechanisms that underlie the developing conditions.

Wilhelm von Waldeyer: Important Steps in Neural Theory, Anatomy and Citology.

Heinrich Wilhelm Gottfried von Waldeyer-Harz is regarded as a significant anatomist who helped the entire medical world to discover and develop new techniques in order to improve patient treatment as well as decrease death rates. He discovered fascia propria recti in 1899, which is important in total mesorectal excision which improves cancer treatment as well as outcomes. He played an important role in developing the neuron theory which states that the nervous system consists of multiple individual cells, called neurons, which currently stands as the basis of the impulse transmission of neurons.

Roadmap to Neurosurgery - from Student to Resident.

Neurosurgery is a medical speciality that diagnoses and treats brain and spine pathologies of infants, children, and adults, having 2 components: clinical and surgical activities. The history of neurosurgery dates back to the Prehistoric Period when first trepanations took place. However, the extensive amount of information we use today was discovered and invented thanks to Joseph Lister (1827-1912), William T.

George Gershwin (1898-1937) - genius composer, malignant brain tumor patient. Malignant glioma: an irritating∕stimulating element in triggering geniality?

George Gershwin (1898-1937) was one of the most influential American composers of the 20th century. Likewise his swift, comet-like, career progress from a high school dropout to an iconic composer of the 20th century: "The man who said he had more notes in his head than he could write down in a hundred years died suddenly ..

Characteristics and Surgical Outcomes of Pediatric Intracranial Aneurysms in Romania.

Aim: To analyze the demographic characteristics and surgical outcomes of the largest series of patients with pediatric aneurysms reported in Romania, in consideration of the primary factors that lead to good long-term outcomes. Given that all cases involved ruptured aneurysms, we also investigated the ability of microsurgical clipping to prevent massive hemorrhage andaggravation of neurological deficits.

Material And Methods: This multicenter retrospective study included 47 pediatric patients ( < 16 years old) who underwent operation over the 20-year period between January 1999 and January 2019.

Intradiploic epidermoid cysts - a series of three cases and our experience with literature data.

Intracranial epidermoid cysts are rare, representing almost 1% of all primary tumors and when are located in the diploe result from entrapped ectodermal embryonic remnants. Because of frequent complications, imaging studies are mandatory for highlighting erosions of both outer and inner table of the calvaria and treatment preparation. We enlisted three female patients within our study, comparing imaging with histopathology aspects.

100 Years since the birth of Ladislau Steiner. Creativity of Neurosurgery.

Ladislau Steiner (1920-2013) was a Romanian neurosurgeon, born in the historic and picturesque region of Făgăraş. He was educated by some of the best doctors and professors in Romania, during the communist regime. After his escape through the communist regime, in 1961, at 41 years old, he started his neurosurgical and radiosurgical career at Karolinska Institute, in Stockholm, under the renown Herbert Olivecrona and Lars Leksell.

Nanoparticles and Nanostructured Surface Fabrication for Innovative Cranial and Maxillofacial Surgery.

A novel strategy to improve the success of soft and hard tissue integration of titanium implants is the use of nanoparticles coatings made from basically any type of biocompatible substance, which can advantageously enhance the properties of the material, as compared to its similar bulk material. So, most of the physical methods approaches involve the compaction of nanoparticles versus micron-level particles to yield surfaces with nanoscale grain boundaries, simultaneously preserving the chemistry of the surface among different topographies. At the same time, nanoparticles have been known as one of the most effective antibacterial agents and can be used as effective growth inhibitors of various microorganisms as an alternative to antibiotics.

Leonardo Gigli and the Gigli Saw-Gigli Redivivus.

Just like Raymond M. Peardon Donaghy and Gazi Yasargil changed modern neurosurgery by introducing the surgical microscope into the operating room, so did Leonardo Gigli by developing and using for the first time a tool that allowed faster, easier, and safer opening of the skull. The invention of the simple but brilliant Gigli saw represented a game changer for practitioners of neurosurgery worldwide.

Remember the Romanian pioneers: Alexandru Obregia (1860-1937) - first in vivo suboccipital puncture.

In a time when doctors had limited knowledge about neuroanatomy and were focused primarily on clinical data, paraclinical investigations were overlooked even though they offered much needed information about the patients. Prof. Dr.

Leonardo da Vinci - ingenious anatomist: 500 years since the death of the famous erudite.

Born on April 15, 1452, in a modest family in a hamlet from Tuscany, Leonardo da Vinci became the unassailable icon of Renaissance. Pushed throughout his entire life by his relentless curiosity, he was a painter, draughtsman, sculptor, poet, musician, writer, engineer, stage designer, architect, physicist, astronomer, cartographer and anatomist. His earliest surviving anatomical drawings (ca.

Remember: Ambroise Paré (1510-1590) - message for young surgeons.

Ambroise Paré was a renowned French barber-surgeon, considered by many to be "the father of surgery". Originating from a family of barber-surgeons, he unraveled the secrets surgery at an early age, and he masters it by participating in the many military actions of the French Army of those times. As recognition of his merits, the kings of France proclaimed him their chief barber-surgeon and even president of the Royal College of French Surgeons.