Evaluation of magnetic hyperthermia, drug delivery and biocompatibility (bone cell adhesion and zebrafish assays) of trace element co-doped hydroxyapatite combined with Mn-Zn ferrite for bone tissue applications.

The treatment and regeneration of bone defects, especially tumor-induced defects, is an issue in clinical practice and remains a major challenge for bone substitute material invention. In this research, a composite material of biomimetic bone-like apatite based on trace element co-doped apatite (Ca M (PO)(CO)(OH); M = trace elements of Mg, Fe, Zn, Mn, Cu, Ni, Mo, Sr and BO ; THA)-integrated-biocompatible magnetic Mn-Zn ferrite ((Mn, Zn)FeO nanoparticles, BioMags) called THAiBioMags was prepared a co-precipitation method. Its characteristics, , physical properties, hyperthermia performance, ion/drug delivery, were investigated using osteoblasts (bone-forming cells) and using zebrafish.

Development of Biomaterials Based on Biomimetic Trace Elements Co-Doped Hydroxyapatite: Physical, In Vitro Osteoblast-like Cell Growth and In Vivo Cytotoxicity in Zebrafish Studies.

Synthesized hydroxyapatite (sHA)-calcium phosphate (CaP) based biomaterials play a vital role and have been widely used in the process of bone regeneration for bone defect repair, due to their similarities to the inorganic components of human bones. However, for bone tissue engineering purpose, the composite components, physical and biological properties, efficacy and safety of sHA still need further improvements. In this work, we synthesized inhomogeneous hydroxyapatite based on biomimetic trace elements (Mg, Fe, Zn, Mn, Cu, Ni, Mo, Sr, Co, BO, and CO) co-doped into HA (THA) (CaM(PO)(CO)(OH), M = trace elements) via co-precipitation from an ionic solution.

Foldable paper-based analytical device for membraneless gas-separation and determination of iodate based on fluorescence quenching of gold nanoclusters.

A new design of a paper-based analytical device (PAD) for membraneless gas-separation with subsequent determination of iodate is presented. The rectangular PAD was invented as the folded pattern, where two circular reservoirs: the donor reservoir and the acceptor reservoir were situated in "a single paper" for convenient use. The hydrophobic barrier of each reservoir was easily fabricated by painting with a permanent marker.

Biodegradable poly(vinyl alcohol)/polyoxalate electrospun nanofibers for hydrogen peroxide-triggered drug release.

Release of drugs in a controlled and sustainable manner is of great interest for treating some inflammatory diseases, drug delivery, and cosmetics. In this work, we demonstrated the control release of a drug from composite nanofibers mediated by hydrogen peroxide. Composite nanofibers of polyvinyl alcohol (PVA)/polyoxalate (PVA/POX NFs) blended at various weight ratios were successfully prepared by electrospinning.