The administration of bovine hydroxyapatite-alendronate implant accelerates bone defect healing in an osteoporotic rat.

Background: Bone fracture is the main consequence of osteoporosis, which may become a neglected disease.

Objective: This study aims to fabricate bovine hydroxyapatite-gelatine (BHA-GEL) based bone-implant with alendronate (ALE) in vivo.

Methods: Wistar rats were used for an osteoporotic animal model induced by ovariectomy.