Publications by authors named "Augusto Ventura da Silva"
Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges.
Vaccines (Basel)
October 2023
Dogs with visceral leishmaniasis play a key role in the transmission cycle of to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, Leish-tec and LetiFend, have limited effectiveness.
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- * After many years of research, the WHO has approved the RTS,S malaria vaccine for use in children in high-risk areas, but further enhancements are needed for better effectiveness against the disease.
- * The review highlights innovative vaccine design strategies, particularly multi-component vaccines and transmission-blocking vaccines (TBVs), aimed at disrupting the parasite’s lifecycle to improve malaria control efforts.
Article Synopsis
- * Vaccination presents a safer, environmentally-friendly alternative, with vaccines like TickGARD® and Gavac® showing varying success in different regions.
- * Research is ongoing to identify and test more effective antigens for tick vaccines, aiming to improve efficacy and potentially provide cross-reactivity against other tick species and diseases.
Ticks are considered the most important vectors in veterinary medicine with a profound impact on animal health worldwide, as well as being key vectors of diseases affecting household pets. The leading strategy applied to dog tick control is the continued use of acaricides. However, this approach is not sustainable due to surging tick resistance, growing public concern over pesticide residues in food and in the environment, and the rising costs associated with their development.
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