Publications by authors named "Augusto Poropat"
Purpose: There is increasing evidence that photobiomodulation (PBM) therapy is both an effective and safe approach in hematopoietic stem cell transplantation (HSCT) for both prevention and management of oral mucositis (OM), but its use in clinical practice is still limited and the timing of application is under discussion. The aim of this retrospective study was to evaluate possible differences between patients treated either with preventive or curative PBM therapy.
Methods: The retrospective case series included 24 patients suffering from multiple myeloma who underwent the same conditioning and transplantation protocol.
Article Synopsis
- Special Needs Patients (SNPs) and uncooperative children often face a higher risk of oral health issues due to limited access to dental care and collaboration challenges.
- A study over six years analyzed 131 SNPs who received dental treatments mainly under general anesthesia, with 90% of cases falling in this category; patients were divided into groups based on their specific conditions.
- The results showed that patients with mental or behavioral disorders required more invasive treatments, but only 5.3% needed additional interventions, highlighting the importance of enhancing parental awareness about oral hygiene and regular dental visits to improve follow-up adherence.
Background: Dentin hypersensitivity is one of the most common complains faced by dental professionals, and there is still lack of consensus for the most effective treatment approaches. The aim of the present study was to evaluate the efficacy of ozone therapy combined with sodium fluoride in reducing pain associated with dental hypersensitivity, compared to a paint-on adhesive desensitizing agent.
Methods: The study included 20 patients (131 teeth), selected according to specific inclusion criteria and divided into two groups according to the type of desensitizing therapy (ozone with sodium fluoride or paint-on adhesive).
Article Synopsis
- The study aimed to assess the knowledge and awareness of oral cancer among a sample of 750 individuals, with a focus on the impact of demographic factors.
- About 68.4% of participants were aware of oral cancer, mainly through media and social circles, with awareness linked to gender and education level but not age.
- The study highlighted misinformation about oral cancer risk factors, particularly concerning amalgam fillings, and emphasized the need for targeted awareness campaigns involving schools and healthcare professionals.
Objective: To better characterize the histopathology of oral lichen planus and oral lichenoid lesions and to highlight the differences between them in order to support the clinician in the diagnostic and therapeutic management of such conditions.
Subjects And Methods: Fifty-five patients, clinically diagnosed with oral lichen planus (n = 25) or oral lichenoid lesions (n = 30), were consecutively enrolled in the present study. Subsequently, one blind pathologist reviewed all the biopsy specimens of enrolled subjects following a specific protocol to provide a detailed histopathological description.
Article Synopsis
- Oral mucositis (OM) is a serious side effect of cancer treatments that can impair quality of life and lead to therapy interruptions.
- Photobiomodulation (PBM) is being studied as a potential solution to promote faster healing and may help manage inflammation and microorganisms in the mouth.
- A pilot study found that PBM reduced harmful pro-inflammatory cytokines, increased beneficial anti-inflammatory cytokines, and improved the overall balance of the oral microbiome, especially in patients who responded well to the treatment.
Background: The objective of this retrospective study was to characterize the outpatient oral medicine referral pattern for tongue lesions with particular emphasis on cancer.
Methods: Records of patients referred to the Oral Medicine department for any tongue lesions needing biopsy between 2009 and 2016 were retrospectively analyzed. All cases diagnosed as tongue cancer were screened for medical history, referral pattern, treatment/diagnosis/follow-up.
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is a common but underrecognized cancer, strongly linked to lifestyle choices like smoking and alcohol use.
- A campaign aimed at raising awareness about oral cancer was conducted in six schools with 460 students aged 12-14 years, including a lecture and anonymous questionnaires to assess knowledge before and after.
- The results showed a dramatic increase in awareness after the lecture, with students rating the campaign highly, indicating that educational efforts can effectively enhance knowledge about cancer risk factors related to lifestyle.
Photobiomodulation (PBM) is emerging as an effective strategy for the management of multiple inflammatory conditions, including oral mucositis (OM) in cancer patients who receive chemotherapy or radiotherapy. Still, the poor understanding of the mechanisms by which the light interacts with biological tissues and the heterogeneity of light sources and protocols employed worldwide significantly limits its applicability. Reactive oxygen species (ROS) are massively generated during the early phases of OM and play a major role in the pathogenesis of inflammation in general.
View Article and Find Full Text PDFObjectives: This preliminary randomized double-blind controlled trial was performed to test the efficacy of ultramicronized palmitoylethanolamide treatment in the burning mouth syndrome.
Materials And Methods: Patients with referred burning mouth intensity greater than 4, according to the Numeric Rating Scale, were included in the study according to established inclusion and exclusion criteria. Patients were randomized into two groups and received either placebo or ultramicronized palmitoylethanolamide 600 mg twice daily for 60 days.
Introduction: Laser Therapy (LT) has been employed for the treatment of Oral Mucositis (OM) due to its anti-inflammatory, analgesic and bio-stimulatory effects.
Objective: This pilot study investigated the effect of LT on the expression of DEFB1, DEFB4, DEFB103 genes encoding for the human β-defensins 1, 2 and 3.
Materials And Method: TR146 epithelial cell line, used to mimic oral mucosa, was irradiated with different LT protocols.