Publications by authors named "Augusto Latorre"
Article Synopsis
- Hematopoiesis, the process of forming blood cells after birth, is traditionally thought to rely solely on hematopoietic stem cells (HSCs) in the bone marrow.
- New findings reveal that a significant portion of lymphocytes, crucial components of the immune system, actually originate from endothelial cells during early embryonic development, rather than from HSCs.
- This research suggests that the role of HSCs in the immune system is not as central as previously believed, highlighting a complex developmental process from embryo to adulthood.
Recent advances in developmental immunology have revealed a hematopoietic stem cell (HSC)-independent origin for various innate immune lineages, including mast cells (MCs). It is now established that adult bone marrow (BM) long-term HSCs do not regenerate MCs but, instead, the physiological production of MCs starts before the emergence of HSCs in the aorta-gonad-mesonephros (AGM) region and is mostly completed before birth. However, while the AGM region represents a major site of MC generation during ontogeny, whether the first emerging HSCs in the AGM or fetal liver (FL) possess the potential to regenerate MCs is unknown.
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