Publications by authors named "Augustinus G Haribowo"
Article Synopsis
- Oxygen deprivation and excess are both toxic, making the body's adaptation to oxygen levels crucial for survival.
- The study investigates protein turnover rates in mouse heart, lung, and brain under different oxygen levels, finding that the lung shows the most significant response.
- It highlights that certain extracellular matrix proteins stabilize in the lung during both low (hypoxia) and high (hyperoxia) oxygen, while a component of the electron transport chain becomes unstable in high oxygen, implicating MYBBP1A as a regulator in this context.
Oxygen is toxic across all three domains of life. Yet, the underlying molecular mechanisms remain largely unknown. Here, we systematically investigate the major cellular pathways affected by excess molecular oxygen.
View Article and Find Full Text PDFOxygen deprivation can be detrimental. However, chronic hypoxia is also associated with decreased incidence of metabolic syndrome and cardiovascular disease in high-altitude populations. Previously, hypoxic fuel rewiring has primarily been studied in immortalized cells.
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