Publications by authors named "Augustin L Longo"
Circulating Proprotein Convertase Subtilisin/Kexin type 9 level independently predicts incident cardiovascular events and all-cause mortality in hemodialysis black Africans patients.
BMC Nephrol
March 2022
Background: Cardiovascular (CV) disease is the leading cause of mortality in patients with end-stage kidney disease (ESKD). The aim of the present study was to determine whether Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) could be an independent predictor of CV events and all-cause mortality in black African haemodialysis patients.
Methods: We carried out a prospective cohort study of all consecutive hemodialysis (HD) patients between August 2016 and July 2020, admitted in six hemodialysis centers of Kinshasa, Democratic Republic of Congo.
SARS-CoV2 infection in symptomatic patients: interest of serological tests and predictors of mortality: experience of DR Congo.
BMC Infect Dis
January 2022
Background: In symptomatic patients, the diagnostic approach of COVID-19 should be holistic. We aimed to evaluate the concordance between RT-PCR and serological tests (IgM/IgG), and identify the factors that best predict mortality (clinical stages or viral load).
Methods: The study included 242 patients referred to the University hospital of Kinshasa for suspected COVID-19, dyspnea or ARDS between June 1st, 2020 and August 02, 2020.
Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels Predict Future Cardiovascular Event Risks in Hemodialyzed Black African Patients.
Rambam Maimonides Med J
July 2021
Context And Objective: Cardiovascular diseases are the leading cause of mortality in patients. In this context, proprotein convertase subtilisin/kexin type 9 (PCSK9) appears to be the new biomarker identified as interfering in lipid homeostasis. This study aimed to investigate the association between PCSK9, dyslipidemia, and future risk of cardiovascular events in a population of black Africans.
View Article and Find Full Text PDFPrognostic Significance of Abnormal Ankle-Brachial Index Among Long-term Hemodialysis Patients in Kinshasa, the Democratic Republic of the Congo.
Rambam Maimonides Med J
January 2021
Objective: Early identification of atherosclerosis using a non-invasive tool like ankle-brachial index (ABI) could help reduce the risk for cardiovascular disease among long-term hemodialysis patients. The study objective was to assess the frequency and impact of abnormal ABI as a marker of subclinical peripheral artery disease (PAD) in chronic hemodialysis patients.
Methods: This was a historic cohort study of kidney failure patients on long-term hemodialysis for at least 6 months.
Article Synopsis
- - Valvular calcifications (VCs) are a serious health concern for patients undergoing chronic hemodialysis (HD), leading to higher morbidity and mortality rates.
- - A study involving 60 HD patients in Kinshasa found that VCs were present in 38% of participants, primarily affecting the aortic valve (64%) and to a lesser extent the mitral valve (23%).
- - Key risk factors linked to VCs included hypertension, age over 60, tobacco use, and high phosphorus levels, suggesting that both common and kidney disease-specific factors contribute to this condition.
Prevalence and factors associated with pulmonary arterial hypertension on maintenance hemodialysis patients in Kinshasa, Democratic Republic of Congo: a cross-sectional study.
BMC Nephrol
November 2020
Article Synopsis
- A study was conducted to investigate the prevalence of Pulmonary Arterial Hypertension (PAH) among chronic hemodialysis patients in sub-Saharan Africa, where its impact remains largely unknown.
- The study included 85 patients, finding a prevalence of PAH at 29.4%, with associated factors such as unsecured healthcare funding and cardiovascular complications like arrhythmia and diastolic dysfunction.
- The results suggest that about one third of hemodialysis patients suffer from PAH, highlighting a connection between this condition and socioeconomic challenges as well as cardiovascular health issues.
Cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) increases with the development of albuminuria and is related in part to dyslipidemia. The present analysis assessed lipid profile and patterns of dyslipidemia in T2DM patients according to albuminuria status. This was a post hoc analysis of data from 181 T2DM patients seen at a tertiary health-care hospital and enrolled in a cross-sectional study of albuminuria status.
View Article and Find Full Text PDFContext And Objective: In the estimation of glomerular filtration rate (GFR), ethnicity is an important determinant. However, all existing equations have been built solely from Caucasian and Afro-American populations and they are potentially inaccurate for estimating GFR in African populations. We therefore evaluated the performance of different estimated GFR (eGFR) equations in predicting measured GFR (mGFR).
View Article and Find Full Text PDFBackground: Oxidative stress is thought to be involved in the pathogenesis of microalbuminuria in Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed to evaluate the association between albuminuria and these two antioxidant enzymes.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the prevalence of low estimated glomerular filtration rate (eGFR), proteinuria, and their risk factors in HIV-infected black patients receiving primary health care.
- A total of 300 HIV-infected patients were screened, with findings showing low eGFR in 3% to 10% of patients and proteinuria in 20.5%, with lower CD4(+) counts linked to lower kidney function.
- Key determinants of renal issues included age, family history of diabetes, and hypertension, highlighting the critical role of antiretroviral therapy in managing chronic kidney disease among this population.