Publications by authors named "August Blomgren"
Reliable dosimetry systems are crucial for radiobiological experiments either to quantify the biological consequences of ionizing radiation or to reproduce results by other laboratories. Also, they are essential for didactic purposes in the field of radiation research. Professional dosemeters are expensive and difficult to use in exposure facilities with closed exposure chambers.
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- Fibroblast activation protein (FAPI) is gaining attention as a target for imaging various cancers using radiolabeled inhibitors, but no clear imaging protocols have been established yet.
- This study aimed to determine if the time required for FAPI PET/CT imaging could be shortened from 4 minutes to 3 minutes per bed position without compromising image quality or diagnostic capability.
- Results showed that while images taken at 3 minutes had acceptable quality, those taken at 1 and 2 minutes were significantly worse than those at 4 minutes, indicating that a reduction in acquisition time could be feasible but with limits to maintain image integrity.
Patients with HER2-low metastatic breast cancer (mBC), defined as an immunohistochemistry (IHC) score of 1+ or 2+ without HER2 gene amplification, may benefit from HER2 antibody-drug conjugates. Identifying suitable candidates is a clinical challenge because of spatial and temporal heterogeneity in HER2 expression and discrepancies in pathologic reporting. We aimed to investigate the feasibility and safety of HER2-specific PET imaging with [Ga]Ga-ABY-025 for visualization of HER2-low mBC.
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