Fluorescence Lifetime and Spectral Characteristics of Subretinal Drusenoid Deposits and Their Predictive Value for Progression of Age-Related Macular Degeneration.

Purpose: To measure fundus autofluorescence (FAF) lifetimes and peak emission wavelengths (PEW) of subretinal drusenoid deposits (SDD) in age-related macular degeneration (AMD) and their development over time.

Methods: Fluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in 30 eyes with optical coherence tomography (OCT)-confirmed early or intermediate AMD and SDD. Contrasts of mean lifetimes in short- (SSC) and long-wavelength channels (LSC), PEW, and relative fluorescence intensity were determined as differences of the respective measures at individual SDD and their environment.

Changes in drusen-associated autofluorescence over time observed by fluorescence lifetime imaging ophthalmoscopy in age-related macular degeneration.

Purpose: To observe fundus autofluorescence (FAF) lifetimes and peak emission wavelength (PEW) of drusen with respect to the pathology of the overlying RPE in the follow-up of AMD-patients.

Methods: Forty eyes of 38 patients (age: 75.1 ± 7.

Optic disc blood perfusion and oxygenation in glaucoma.

Purpose: To investigate the haemoglobin concentration and oxygenation in the optic disc in glaucoma patients vs. controls.

Methods: Thirty-one eyes of primary open angle glaucoma patients (mean age: 64.

Fundus Autofluorescence Lifetimes and Spectral Features of Soft Drusen and Hyperpigmentation in Age-Related Macular Degeneration.

Purpose: To investigate the autofluorescence lifetimes as well as spectral characteristics of soft drusen and retinal hyperpigmentation in age-related macular degeneration (AMD).

Methods: Forty-three eyes with nonexudative AMD were included in this study. Fluorescence lifetime imaging ophthalmoscopy (FLIO), which detects autofluorescence decay over time in the short (SSC) and long (LSC) wavelength channel, was performed.

Simplified approach to least-square fitting of fluorescence lifetime ophthalmoscopy (FLIO) data by fixating lifetimes.

Fluorescence lifetime imaging ophthalmoscopy (FLIO) is a new imaging modality in ophthalmology. For clinical investigations, the amplitude-weighted mean of two or three lifetime components is usually analyzed. In this study, we investigated the effects of fixation of lifetime components.

The flicker response of venous oxygen saturation is significantly reduced in the early and late stages of age-related macular degeneration.

Background: Retinal oxygen saturation (SO2) during flicker light stimulation was measured non-invasively in humans with age-related macular degeneration (AMD). Furthermore, the differences between early and late stages of AMD were evaluated.

Methods: In 60 eyes of 45 AMD patients (74 ± 8.

[Infection-associated Acute Posterior Multifocal Placoid Pigment Epitheliopathy].

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory chorioretinopathy, which mainly affects young light-skinned, myopic adults between 20 and 30 years of age. The exact aetiology of APMPPE is unknown. Some patients report a viral or flu-like illness preceding the onset of APMPPE symptoms.

Monitoring macular pigment changes in macular holes using fluorescence lifetime imaging ophthalmoscopy.

Purpose: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH).

Methods: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated.

Fundus autofluorescence lifetimes are increased in non-proliferative diabetic retinopathy.

Purpose: To discriminate non-proliferative diabetic retinopathy (NPDR) patients from healthy controls by fluorescence lifetime imaging ophthalmoscopy (FLIO).

Methods: A prototype FLIO (Heidelberg-Engineering, Heidelberg, Germany) was used to examine the retina of 33 patients and 28 controls. As increased fluorescence of the diabetic lens is known, the lenses of 34 patients and 24 controls were investigated as well.

Impact of Macular Pigment on Fundus Autofluorescence Lifetimes.

Purpose: To characterize the macular region and to investigate the influence of the macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo.

Methods: Forty-eight healthy subjects with a mean age of 24.1 ± 3.

Dependence of diameters and oxygen saturation of retinal vessels on visual field damage and age in primary open-angle glaucoma.

Purpose: To investigate the interrelationship between the oxygen supply of the retina and its regulation with the severity of primary open-angle glaucoma (POAG).

Methods: Central retinal artery (CRAE) and vein (CRVE) diameters and oxygen saturation of peripapillary retinal vessels in 41 patients suffering from POAG (64.1 ± 12.

Investigation of blood flow regulation and oxygen saturation of the retinal vessels in primary open-angle glaucoma.

Purpose: To examine the supply of oxygen to the retina in primary open-angle glaucoma (POAG).

Methods: Forty-one patients with primary open-angle glaucoma (mean age 64.1 ± 12.

[Study on the time course of macular pigment density measurement in patients with a macular hole--clinical course and impact of surgery].

Background: In a prospective clinical study we examined the course of the optical density of the macular pigment (MPOD) in patients with idiopathic macular holes before and after pars-plana vitrectomy.

Patients And Methods: Of the 26 patients four had macular holes stage 1, six patients had stage 2 or stage 4 holes and ten people had a macular hole stage 3. The surgical procedure consisted always of a standard 3-port pars plana vitrectomy (PPV) with colouring assisted peeling of the internal limiting membrane.

[Corneal ulcers in systemic autoimmunologic diseases].

Background: Keratolysis is a rare severe complication following systemic autoimmunologic diseases. Despite of complex therapeutic treatments, the prognosis is very poor.

Patients: Ten eyes from seven patients with corneal ulcers were reported (age 45 - 73 years, mean 63 years; 6 women, 1 man).

[Fusarium keratitis].

The case of a previously healthy 48-year-old patient (not a contact lens wearer) with a Fusarium keratitis is reported. He had developed a deep corneal ulcer with total stromal infiltration (Fusarium ssp.).

[Terson syndrome--a contribution to the timing of operation for pars plana vitrectomy].

Purpose: This study aimed to investigate the possible differences in final outcome in patients with Terson syndrome (1996 - 2005) with regard to the time of vitrectomy after the acute event.

Method: Eighteen eyes from eleven patients with Terson syndrome are reported. All eyes showed considerable haemorrhages without any tendency of resorption.