Publications by authors named "Auger N"
Introduction: Preeclampsia is associated with acute neurological complications during pregnancy, but the subsequent risk of developing a neurological disorder is unclear. We determined if preeclampsia was associated with the long-term risk of neurological morbidity.
Methods: We conducted a longitudinal cohort study of 1,460,098 pregnant women with and without preeclampsia in Quebec, Canada, between 1989 and 2023.
Article Synopsis
- This study examined how postpartum preeclampsia affects maternal and neonatal outcomes using data from over 1.3 million pregnancies in Quebec from 2006 to 2022.
- Postpartum preeclampsia was less common than antepartum preeclampsia but was linked to higher risks of preterm birth, placental abruption, and severe maternal complications.
- The research suggests that women who experience postpartum preeclampsia should have their blood pressure monitored for up to six weeks after delivery to identify any adverse effects.
Article Synopsis
- Next-generation sequencing (NGS) has helped uncover genetic causes of primary ovarian insufficiency (POI), while the reasons for diminished ovarian reserve (DOR) are less understood.
- A 14-year-old patient with isolated DOR was found to have two frameshift mutations in the BRCA1 gene, but surprisingly showed no signs of Fanconi anemia (FA).
- Despite the absence of FA symptoms, the patient's cells exhibited high chromosomal fragility, and studies indicated a shortened version of the BRCA1 protein was produced, suggesting that BRCA1 is crucial for ovarian health and functioning.
Background Tumor fraction (TF) at liquid biopsy is a potential noninvasive marker for tumor burden, but validation is needed. Purpose To evaluate TF as a potential surrogate for tumor burden, assessed at contrast-enhanced CT across diverse metastatic cancers. Methods This retrospective monocentric study included patients with cancer and metastatic disease, with TF results and contemporaneous contrast-enhanced CT performed between January 2021 and January 2023.
View Article and Find Full Text PDFThe not-so-simple question of when or if to induce a term pregnancy.
Paediatr Perinat Epidemiol
November 2024
Background: Risk factors for influenza complications in women are poorly understood. We examined the association between pregnancy outcomes and risk of influenza hospitalization up to three decades later.
Methods: We analyzed a cohort of 1,421,531 pregnant women who delivered in Quebec, Canada between 1989 and 2021.
Objective: To evaluate the association between gestational trophoblastic disease and the subsequent risk of developing non-trophoblastic cancer.
Methods: We conducted a retrospective cohort study of 3084 women with gestational trophoblastic disease and 1 415 812 women with obstetric deliveries in Quebec, Canada, between 1989 and 2021. The main exposure was gestational trophoblastic disease, including hydatidiform moles, invasive moles, and gestational choriocarcinoma.
Importance: Hidradenitis suppurativa (HS) is associated with morbidity in persons of reproductive age, but the effect on maternal and offspring outcomes is understudied.
Objective: To determine the association of HS with pregnancy outcomes and maternal and child morbidity in the long term.
Design, Setting, And Participants: This population-based longitudinal cohort study with up to 16 years of follow-up took place between 2006 and 2022 in Quebec, Canada.
Objectives: We examined the ethnic origin of authors who published research articles in leading medical journals over the past 2 decades.
Study Design And Setting: We carried out a serial cross-sectional analysis of first and last authors who published original research articles in the British Medical Journal, Lancet, Journal of the American Medical Association, and New England Journal of Medicine in 2002, 2012, and 2022. The main outcome was the change in proportion of authors over time according to ethnic origin (Anglo, North/West European, South/West European, Asian, Arab and Middle Eastern, African), gender (male, female), and institutional affiliation in percentage points.
Article Synopsis
- * A retrospective study from 2010 to 2021 showed rates rose from 4.11 to 6.76 per 1000 total births after the new definition was implemented, resulting in an absolute increase of 2.58 stillbirths.
- * The increase in stillbirths was largely due to deaths associated with congenital anomalies and pregnancy terminations, with 37% of stillbirths being from fetuses under 500 g and 42% between 20 and 23 weeks gestation.
Pediatric Morbidity Among Black Haitians in Canada: A Longitudinal Cohort Study.
J Racial Ethn Health Disparities
September 2024
Background: In the U.S., Black children have disproportionately elevated rates of pediatric morbidity compared with White children, but data are lacking for other countries.
View Article and Find Full Text PDFIntroduction: In Canada, newborn morbidity far surpasses mortality. The neonatal adverse outcome indicator (NAOI) summarizes neonatal morbidity, but Canadian trend data are lacking.
Methods: This Canada-wide retrospective cross-sectional study included hospital livebirths between 24 and 42 weeks' gestation, from 2013 to 2022.
Aim: To examine the relationship between preterm birth and hospitalisation for paediatric complex chronic conditions.
Methods: We conducted a cohort study of 1 269 745 children born between 2006 and 2022 in Quebec, Canada. We classified preterm birth as extreme (<28 weeks), very (28-31 weeks), and moderate (32-36 weeks).
Article Synopsis
- The study evaluated how the COVID-19 pandemic affected pregnancy outcomes in 443,101 patients who either conceived naturally or through assisted reproductive technology in Quebec, Canada, between December 2015 and July 2021.
- It found that while assisted reproductive technology was linked to higher risks of preeclampsia, preterm birth, and low birth weight during the pandemic, similar risks were already present before the pandemic, indicating that COVID-19 itself may not have altered these outcomes significantly.
- Overall, the research suggests that the pandemic did not have a major adverse effect on pregnancy outcomes for women using assisted reproductive technology, providing reassurance to patients concerned about fertility during this time.
Validation of Database Autopsy for Review of Pregnancy-Associated Deaths in Canada.
J Obstet Gynaecol Can
September 2024
The database autopsy method was developed to determine probable causes of maternal deaths in the Canadian Institute for Health Information's hospital discharge abstract database; however, the method has yet to be validated. Using immediate cause of death information from Québec's hospitalization database as the gold standard, this study assessed the validity and reliability of the database autopsy method for pregnancy-associated deaths. The method had high sensitivity and specificity for identifying the most common causes of these deaths, as well as high interobserver agreement.
View Article and Find Full Text PDFObjectives: We examined long-term outcomes of toxic shock syndrome.
Methods: We conducted a matched cohort study of 630 patients with toxic shock syndrome and 5009 healthy controls between 2006 and 2021 in Quebec, Canada. Outcomes included hospitalization for renal, cardiovascular, hepatic, and other morbidity during 15 years of follow-up.
Article Synopsis
- Maternal hyperemesis gravidarum (HG) is linked to long-term health issues in children, potentially increasing their risk of hospitalization for various medical conditions.
- In a study involving over 1.1 million children in Quebec, those exposed to HG were found to have higher hospitalization rates compared to those unexposed, with a 21% increased risk overall.
- The study highlighted that HG particularly raises the risk for neurologic, developmental, digestive, and allergic disorders in children, indicating that it poses greater risks than preeclampsia.
Objective: To investigate the risk of adverse neonatal events after a pregnancy complicated by severe maternal morbidity.
Study Design: We analyzed a population-based cohort of deliveries in Quebec, Canada, between 2006 and 2021. The main exposure measure was severe maternal morbidity, comprising life-threatening conditions such as severe hemorrhage, cardiac complications, and eclampsia.
Article Synopsis
- A study in Quebec examined over 1.4 million women to see if non-cardiac birth defects affect the risk of cardiovascular hospitalisation.
- Results showed that women with any birth defect had a significantly higher rate of cardiovascular hospitalisation compared to those without defects, with non-cardiac defects increasing the risk 1.61 times.
- Specific non-cardiac defects, especially urinary and central nervous system defects, were linked to higher risk, though cardiac defects posed the greatest risk overall.
Article Synopsis
- Severe maternal morbidity (SMM) can significantly affect a mother's long-term health, particularly her mental well-being, but little research has focused on this connection.
- This study investigates the impact of experiencing SMM during a first childbirth on the likelihood of subsequent hospitalizations or emergency visits for mental health issues over a 13-year period in Canada.
- Out of over 2 million postpartum individuals analyzed, 2.3% experienced SMM, and the results suggest a higher risk for mental health problems in those affected, taking into consideration various maternal demographics and health factors.
Purpose: We assessed the risk of congenital anomalies in children who have a sibling with cancer.
Methods: We performed a matched cohort study of children born between 2006 and 2022 in Quebec. The exposure was having a sibling with cancer.