Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership Fragile X Syndrome.

Recent failures translating preclinical behavioral treatment effects to positive clinical trial results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological pathways and associated measures, such as electroencephalography (EEG), with strong translational potential and small molecule target engagement. This study utilized guided machine learning to test promising translational EEG measures (resting power and auditory chirp oscillatory variables) in a large heterogeneous sample of individuals with FXS to identify best performing EEG variables for reliably separating individuals with FXS, and genetically-mediated subgroups within FXS, from typically developing controls. Best performing variables included resting relative frontal theta power, all combined posterior-head resting power bands, posterior peak alpha frequency (PAF), combined PAF across all measured regions, combined theta, alpha, and gamma power during the chirp, and all combined chirp oscillatory variables.

On the implementation of acollinearity in PET Monte Carlo simulations.

Acollinearity of annihilation photons (APA) introduces spatial blur in positron emission tomography (PET) imaging. This phenomenon increases proportionally with the scanner diameter and it has been shown to follow a Gaussian distribution. This last statement can be interpreted in two ways: the magnitude of the acollinearity angle, or the angular deviation of annihilation photons from perfect collinearity.

Devaluation of Attractive Alternatives: How Those With Poor Inhibitory Ability Preemptively Resist Temptation.

How do people resist in-the-moment temptation if they are poor at inhibiting their impulses? Theory on self-control suggests that people have a toolbox of strategies available to them that may be used to dampen temptations. Applying this to the goal of relationship maintenance, in two studies, we examined whether people motivated to maintain their romantic relationship but poor at inhibitory control would appraise an attractive alternative (AA) as less appealing prior to a face-to-face interaction. In Study 1 ( = 190), those with high motivation and low inhibitory control (measured with the Stroop) rated the AA as less appealing as compared with singles and those high in motivation and inhibitory control.

On Creating Deeper Relationship Bonds: Felt Understanding Enhances Relationship Identification.

Relational experiences play a critical role in shaping how individuals see themselves. In four studies (=945) using person-perception, longitudinal, and experimental designs, we demonstrate that feeling understood changes individuals' self-concept by increasing the centrality of a specific relationship (relationship identification). Study 1 showed that participants perceived an individual to be more identified with their relationship when their partner was high (vs.

Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership Fragile X Syndrome.

Recent failures translating preclinical behavioral treatment effects to positive clinical trial results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological pathways and associated measures, such as electroencephalography (EEG), with strong translational potential and small molecule target engagement. This study utilized guided machine learning to test promising translational EEG measures (resting power and auditory chirp oscillatory variables) in a large heterogeneous sample of individuals with FXS to identify best performing EEG variables for reliably separating individuals with FXS, and genetically-mediated subgroups within FXS, from typically developing controls. Best performing variables included resting relative frontal theta power, all combined whole-head resting power bands, posterior peak alpha frequency (PAF), combined PAF across all measured regions, combined theta, alpha, and gamma power during the chirp, and all combined chirp oscillatory variables.

The multiple indicator multiple cause model for cognitive neuroscience: An analytic tool which emphasizes the behavior in brain-behavior relationships.

Cognitive neuroscience has inspired a number of methodological advances to extract the highest signal-to-noise ratio from neuroimaging data. Popular techniques used to summarize behavioral data include sum-scores and item response theory (IRT). While these techniques can be useful when applied appropriately, item dimensionality and the quality of information are often left unexplored allowing poor performing items to be included in an itemset.

Independent evaluation of the harvard automated processing pipeline for Electroencephalography 1.0 using multi-site EEG data from children with Fragile X Syndrome.

Background: The Harvard Automatic Processing Pipeline for Electroencephalography (HAPPE) is a computerized EEG data processing pipeline designed for multiple site analysis of populations with neurodevelopmental disorders. This pipeline has been validated in-house by the developers but external testing using real-world datasets remains to be done.

New Method: Resting and auditory event-related EEG data from 29 children ages 3-6 years with Fragile X Syndrome as well as simulated EEG data was used to evaluate HAPPE's noise reduction techniques, data standardization features, and data integration compared to traditional manualized processing.

Four Decades of Military Posttraumatic Stress: Protocol for a Meta-analysis and Systematic Review of Treatment Approaches and Efficacy.

Background: Over 85% of active members of the Canadian Armed Forces have been exposed to potentially traumatic events linked to the development of posttraumatic stress disorder (PTSD). At the time of transition to civilian life, as high as 1 in 8 veterans may be diagnosed with PTSD. Given the high prevalence of PTSD in military and veteran populations, the provision of effective treatment considering their unique challenges and experiences is critical for mental health support and the well-being of these populations.

Risk and Resilience Factors During the COVID-19 Pandemic: A Snapshot of the Experiences of Canadian Workers Early on in the Crisis.

Research highlights several risk and resilience factors at multiple ecological levels that influence individuals' mental health and wellbeing in their everyday lives and, more specifically, in disaster or outbreak situations. However, there is limited research on the role of these factors in the early days of the COVID-19 crisis. The present study examined if and how potential risk factors (i.

Happy prenatal relationships, healthy postpartum mothers: a prospective study of relationship satisfaction, postpartum stress, and health.

Major life transitions, such as the arrival of a new baby, can be stressful, and therefore, costly to one's health. Being in a satisfying romantic relationship has been previously linked with better health, perhaps because it provides access to a bank of psychosocial resources. The objective of the present research was two-fold.

Biased Agonist TRV027 Determinants in AT1R by Molecular Dynamics Simulations.

Functional selectivity is a phenomenon observed in G protein-coupled receptors in which intermediate active-state conformations are stabilized by mutations or ligand binding, resulting in different sets of signaling pathways. Peptides capable of selectively activating β-arrestin, known as biased agonists, have already been characterized in vivo and could correspond to a new therapeutic approach for treatment of cardiovascular diseases. Despite the potential of biased agonism, the mechanism involved in selective signaling remains unclear.

Activation of the Behavioral Immune System: Putting the Brakes on Affiliation.

Evolutionary psychologists propose that humans evolved a first line of defense against pathogens: the behavioral immune system (BIS). The BIS is thought to be functionally flexible such that the likelihood and magnitude of BIS activation depends on the individual's perceived vulnerability to disease (PVD). Because conspecifics are sources of infection, the BIS has implications for affiliation.

Effectiveness of Service Dogs for Veterans with PTSD: Preliminary Outcomes.

Limited scientific evidence on the effectiveness of psychiatric service dogs used by Veterans with post-traumatic stress disorder (PTSD) is available. This study investigated their short-term effectiveness among 15 Canadian veterans who received a first psychiatric service dog. Preliminary results suggest potential beneficial effects at 3 months on the psychiatric symptoms.

Daily Experiences and Relationship Well-Being: The Paradoxical Effects of Relationship Identification.

Objective: Even couples in healthy romantic relationships experience conflict at times. We examine whether relationship identification (the extent to which the relationship is incorporated into the self) predicts immediate reactivity to partner transgressions and also promotes global resilience over time.

Method: Sixty-three couples participated in a 2-week event-contingent diary study.

Social identity change in response to discrimination.

This study investigated the conditions under which discrimination can lead to social identity changes among members of a minority group. Both positive and negative relations between perceptions of discrimination and social identity have previously been reported. To explain the conflicting results and understand the complex reality of members of stigmatized groups, we argue that group-based emotions (e.

Analysis of forward and backward Second Harmonic Generation images to probe the nanoscale structure of collagen within bone and cartilage.

Collagen ultrastructure plays a central role in the function of a wide range of connective tissues. Studying collagen structure at the microscopic scale is therefore of considerable interest to understand the mechanisms of tissue pathologies. Here, we use second harmonic generation microscopy to characterize collagen structure within bone and articular cartilage in human knees.

Social change in South Africa: a historical approach to relative deprivation.

Dramatic social change involves profound transformations that impact an entire group moving forward. Such is the reality for race relations in South Africa. Research has found that most people report a trajectory of group-based relative deprivation that appears to parallel actual historical events.

Effects of growth conditions on biofilm formation by Actinobacillus pleuropneumoniae.

Biofilm formation is an important virulence trait of many bacterial pathogens. It has been reported in the literature that only two of the reference strains of the swine pathogen Actinobacillus pleuropneumoniae, representing serotypes 5b and 11, were able to form biofilm in vitro. In this study, we compared biofilm formation by the serotype 1 reference strain S4074 of A.

Host-pathogen interactions of Actinobacillus pleuropneumoniae with porcine lung and tracheal epithelial cells.

Host-pathogen interactions are of great importance in understanding the pathogenesis of infectious microorganisms. We developed in vitro models to study the host-pathogen interactions of porcine respiratory tract pathogens using two immortalized epithelial cell lines, namely, the newborn pig trachea (NPTr) and St. Jude porcine lung (SJPL) cell lines.

Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: limited role of LOS in apoptosis and pro-inflammatory cytokine release.

Haemophilus parasuis colonizes the upper respiratory tract of swine and causes Glässer's disease. We recently demonstrated that H. parasuis can adhere to newborn pig tracheal (NPTr) cells.

[Factors associated with organ and tissue donation refusal. Prospective study in the West of France].

Objective: The refusal to permit organ sampling is of around 30% and is one of the principle causes for the lack of sampling. This study was aimed at establishing the frequency of decisions taken with regard to donations and the factors associated with refusal.

Method: A prospective study was conducted between April 2, 2000 and March 31, 2001 in hospitals authorised to perform organ sampling in the Western area of France.

Seismic evidence of an extended magmatic sill under Mt. Vesuvius.

Mt. Vesuvius is a small volcano associated with an elevated risk. Seismic data were used to better define its magmatic system.