Comparison of the DOAC Dipstick Test on Urine Samples With Chromogenic Substrate Methods on Plasma Samples in Outpatients Treated With Direct Oral Anticoagulants.

Identifying adherence to direct oral anticoagulants (DOACs) plays a major role in treatment efficacy and safety. The DOAC Dipstick can detect DOACs in urine samples of acutely diseased patients at plasma thresholds of about 30 ng/mL. A prospective observational consecutive cohort study was performed on outpatients taking DOACs.

Extended cavity quantum cascade laser with cavity resonator integrated grating filter.

We report on an extended cavity quantum cascade laser based on a cavity resonator integrated grating filter (CRIGF) that acts as both cavity end-reflector and spectral selector. Stable, mode-hop free, single-mode emission around 2150 cm is obtained over large injection current ranges (more than 50 mA) with a typical threshold around 290 mA. A digital frequency tuning over more than 65 cm is obtained by changing the periodicity of the CRIGF ending the extended cavity.

Modeling Protein Destiny in Developing Fruit.

Protein synthesis and degradation are essential processes that regulate cell status. Because labeling in bulky organs, such as fruits, is difficult, we developed a modeling approach to study protein turnover at the global scale in developing tomato () fruit. Quantitative data were collected for transcripts and proteins during fruit development.

Mid-infrared cavity resonator integrated grating filters.

Cavity Resonator Grating Filters (CRIGFs) working in the Mid-Infrared are reported, with narrow-band resonant reflectivity peaks around 2200 cm (4.6 µm). They are fabricated in the GaAs/AlGaAs material system that can potentially cover the whole [1-12] µm spectral range.

Tunable graded cavity resonator integrated grating filters.

We demonstrated Graded Cavity Resonator Integrated Grating Filters (G-CRIGFs) that are narrowband spectral reflectors, spectrally tunable over more than 40 nm around 850 nm using a spatial gradient. A simple analytical model is introduced and validated experimentally to determine spectral performance of G-CRIGFs from the spectral properties of a standard Cavity Resonator Integrated Grating Filter (CRIGF).

Differential contributions of STAT5A and STAT5B to stress protection and tyrosine kinase inhibitor resistance of chronic myeloid leukemia stem/progenitor cells.

STAT5 fulfills essential roles in hematopoietic stem cell (HSC) self-renewal and chronic myeloid leukemia (CML), a prototypical stem cell malignancy. However, the specific contributions of the two related genes STAT5A and STAT5B have not been determined. In this study, we used a RNAi-based strategy to establish participation of these genes to CML disease and persistence following targeted therapy.

NMR measure of translational diffusion and fractal dimension. Application to molecular mass measurement.

Experimental NMR diffusion measure on polymers and on globular proteins are presented. These results, complemented with results found in the literature, enable a general description of effective fractal dimension for objects such as small organic molecules, sugars, polymers, DNA, and proteins. Results are compared to computational simulations as well as to theoretical values.

Characterization of substance P-membrane interaction by transferred nuclear Overhauser effect.

Substance P, one of the mammalian tachykinins, is known to interact strongly with lipid bilayers and this interaction may play a role in the receptor-peptide recognition process. The conformation of substance P bound to vesicles consisting of perdeuterated phosphatidylcholine has been investigated by means of two-dimensional transferred nuclear Overhauser (trNOE) spectroscopy. Nuclear magnetic resonance data analysis resulted in a unique conformational family characterized by a well-defined conformation of the last seven C-terminal amino acids, which consists of a sequence of nonstandard turns following each other in a helix-like manner.

Naturalistic observation of athletic drug-use patterns and behavior in professional-caliber bodybuilders.

Athletic performance-enhancing drug use is widespread. Awareness in the medical community lags because various athletic subcultures have not been penetrated by conventional medical literature. This report presents a current and comprehensive assessment of drugs used by professional-caliber bodybuilders to enhance athletic performance.

Structure of a novel glycopeptidolipid antigen containing a O-methylated serine isolated from Mycobacterium xenopi. Complete 1H-NMR and 13C-NMR assignment.

GPL X-1, a novel glycopeptidolipid (GPL) isolated from Mycobacterium xenopi (CIPT 140 35004), has recently been found to typify a new class of mycobacterial glycopeptidolipids devoid of C-mycoside core structure, the so-called serine-containing glycopeptidolipid [Rivière, M. & Puzo, G. (1991) J.