Knock-in Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death.

Background: Long QT Syndrome Type-2 (LQT2) is due to loss-of-function variants. encodes K 11.1 that forms a delayed-rectifier potassium channel in the brain and heart.

Scenarios, not shortage forecasts, are key to better workforce policy.

Current and projected shortages in the US health workforce have prompted policymakers to propose reforms to Medicare Graduate Medical Education (GME) and nursing programs. However, researchers have historically faced challenges in accurately predicting workforce trends; physician and nurse supply and demand all grew faster than expected over the past 2 decades. These discrepancies highlight the need for scenario-based workforce planning and projection models that estimate how a policy intervention would affect the workforce outcome of interest.

Thermal Rates and High-Temperature Tunneling from Surface Reaction Dynamics and First-Principles.

Studying dynamics of the dissociative adsorption and recombinative desorption of hydrogen on copper surfaces has shaped our atomic-scale understanding of surface chemistry, yet experimentally determining the thermal rates for these processes, which dictate the outcome of catalytic reactions, has been impossible so far. In this work, we determine the thermal rate constants for dissociative adsorption and recombinative desorption of hydrogen on Cu(111) between 200 and 1000 K using data from reaction dynamics experiments. Contrary to current understanding, our findings demonstrate the predominant role of quantum tunneling, even at temperatures as high as 400 K.

Cooperative adsorbate binding catalyzes high-temperature hydrogen oxidation on palladium.

Atomic-scale structures that account for the acceleration of reactivity by heterogeneous catalysts often form only under reaction conditions of high temperatures and pressures, making them impossible to observe with low-temperature, ultra-high-vacuum methods. We present velocity-resolved kinetics measurements for catalytic hydrogen oxidation on palladium over a wide range of surface concentrations and at high temperatures. The rates exhibit a complex dependence on oxygen coverage and step density, which can be quantitatively explained by a density functional and transition-state theory-based kinetic model involving a cooperatively stabilized configuration of at least three oxygen atoms at steps.

Neurocardiac pathologies associated with potassium channelopathies.

Voltage-gated potassium channels are expressed throughout the human body and are essential for physiological functions. These include delayed rectifiers, A-type channels, outward rectifiers, and inward rectifiers. They impact electrical function in the heart (repolarization) and brain (repolarization and stabilization of the resting membrane potential).

A promising approach utilising photothermal energy to disinfect the root canal system: An in vitro investigation.

This study aimed to assess root canal disinfection through various irrigation protocols, including a novel photothermal system called 'LEAP'. Mandibular premolars were infected with Enterococcus faecalis and divided into five groups for different treatments: Group 1: standard needle irrigation; Group 2: passive ultrasonic irrigation; Group 3: GentleWave; Group 4: LEAP; and Group 5: Group 1 + Group 4. Microbial counts were measured before (S1) and after disinfection (S2) using colony-forming units (CFU) and confocal laser scanning microscopy (CLSM).

Identification of reaction intermediates in the decomposition of formic acid on Pd.

Uncovering the role of reaction intermediates is crucial to developing an understanding of heterogeneous catalysis because catalytic reactions often involve complex networks of elementary steps. Identifying the reaction intermediates is often difficult because their short lifetimes and low concentrations make it difficult to observe them with surface sensitive spectroscopic techniques. In this paper we report a different approach to identify intermediates for the formic acid decomposition reaction on Pd(111) and Pd(332) based on accurate measurements of isotopologue specific thermal reaction rates.

Projecting the Future Registered Nurse Workforce After the COVID-19 Pandemic.

Importance: Health care delivery systems rely on a well-prepared and adequately sized registered nurse (RN) workforce. The US RN workforce decreased by more than 100 000 in 2021 during the COVID-19 pandemic-a far greater single-year drop than observed over the past 4 decades. The implication for the longer-term growth of the RN workforce is unknown.

Provision of evaluation and management visits by nurse practitioners and physician assistants in the USA from 2013 to 2019: cross-sectional time series study.

Objective: To examine the proportion of healthcare visits are delivered by nurse practitioners and physician assistants versus physicians and how this has changed over time and by clinical setting, diagnosis, and patient demographics.

Design: Cross-sectional time series study.

Setting: National data from the traditional Medicare insurance program in the USA.

Heart rate and autonomic biomarkers distinguish convulsive epileptic vs. functional or dissociative seizures.

Objective: 20-40% of individuals whose seizures are not controlled by anti-seizure medications exhibit manifestations comparable to epileptic seizures (ES), but there are no EEG correlates. These events are called functional or dissociative seizures (FDS). Due to limited access to EEG-monitoring and inconclusive results, we aimed to develop an alternative diagnostic tool that distinguishes ES vs.

Surface-induced vibrational energy redistribution in methane/surface scattering depends on catalytic activity.

Recent state-to-state experiments of methane scattering from Ni(111) and graphene-covered Ni(111) combined with quantum mechanical simulations suggest an intriguing correlation between the surface-induced vibrational energy redistribution (SIVR) during the molecule/surface scattering event and the catalytic activity for methane dissociation of the target surface (Werdecker, Phys. Rev. Res.

Quantum state-resolved methane scattering from Ni(111) and NiO(111) by bolometer infrared laser tagging: The effect of surface oxidation.

We describe a novel ultrahigh vacuum state-to-state molecule/surface scattering apparatus with quantum state preparation of the incident molecular beam and angle-resolved quantum state detection of the scattered molecules. State-resolved detection is accomplished using a tunable mid-infrared laser source combined with a cryogenic bolometer detector and is applicable to any molecule with an infrared-active vibrational transition. Results on rotationally inelastic scattering of CH4 methane from a Ni(111) surface and NiO(111)/Ni(111) oxide film, obtained by the new apparatus, are presented.

Highly Rotationally Excited N Reveals Transition-State Character in the Thermal Decomposition of NO on Pd(110).

We employ time-slice and velocity map ion imaging methods to explore the quantum-state resolved dynamics in thermal NO decomposition on Pd(110). We observe two reaction channels: a thermal channel that is ascribed to N products initially trapped at surface defects and a hyperthermal channel involving a direct release of N to the gas phase from NO adsorbed on bridge sites oriented along the [001] azimuth. The hyperthermal N is highly rotationally excited up to = 52 (″ = 0) with a large average translational energy of 0.

Spin-dependent reactivity and spin-flipping dynamics in oxygen atom scattering from graphite.

The formation of two-electron chemical bonds requires the alignment of spins. Hence, it is well established for gas-phase reactions that changing a molecule's electronic spin state can dramatically alter its reactivity. For reactions occurring at surfaces, which are of great interest during, among other processes, heterogeneous catalysis, there is an absence of definitive state-to-state experiments capable of observing spin conservation and therefore the role of electronic spin in surface chemistry remains controversial.

Comparing ambulatory commercial spending in Rhode Island and Massachusetts, 2016-2019.

Objective: To evaluate trends and drivers of commercial ambulatory spending and price variation.

Data Sources And Study Setting: Commercial claims data from the Massachusetts and Rhode Island All-Payer Claims Databases from 2016 to 2019.

Study Design: Observational study of spending in major ambulatory care settings.

Marriage, Children, and Sex-Based Differences in Physician Hours and Income.

Importance: A better understanding of the association between family structure and sex gaps in physician earnings and hours worked over the life cycle is needed to advance policies addressing persistent sex disparities.

Objective: To investigate differences in earnings and hours worked for male and female physicians at various ages and family status.

Design, Setting, And Participants: This retrospective, cross-sectional study used data on physicians aged 25 to 64 years responding to the American Community Survey between 2005 and 2019.

An overview and policy implications of national nurse identifier systems: A call for unity and integration.

There is a clear and growing need to be able record and track the contributions of individual registered nurses (RNs) to patient care and patient care outcomes in the US and also understand the state of the nursing workforce. The National Academies of Sciences, Engineering, and Medicine report, The Future of Nursing 2020-2030: Charting a Path to Achieve Health Equity (2021), identified the need to track nurses' collective and individual contributions to patient care outcomes. This capability depends upon the adoption of a unique nurse identifier and its implementation within electronic health records.

Binding Energy and Diffusion Barrier of Formic Acid on Pd(111).

Velocity-resolved kinetics is used to measure the thermal rate of formic acid desorption from Pd(111) between 228 and 273 K for four isotopologues: HCOOH, HCOOD, DCOOH, DCOOD. Upon molecular adsorption, formic acid undergoes decomposition to CO and H and thermal desorption. To disentangle the contributions of individual processes, we implement a mass-balance-based calibration procedure from which the branching ratio between desorption and decomposition for formic acid is determined.

Steric Hindrance of NH Diffusion on Pt(111) by Co-Adsorbed O-Atoms.

A detailed velocity-resolved kinetics study of NH thermal desorption rates from (2 × 2) O/Pt(111) is presented. We find a large reduction in the NH desorption rate due to adsorption of O-atoms on Pt(111). A physical model describing the interactions between adsorbed NH and O-atoms explains these observations.

Characteristics of rural registered nurses and the implications for workforce policy.

Purpose: Rural registered nurses (RNs) play an integral role in providing care for an underserved population with worse health outcomes than urban counterparts. However, little information is available on the profile of this workforce, which is necessary to understand the capacity of these nurses to provide quality and demanded care presently and in the future.

Methods: We utilize data from the American Community Survey to provide a contemporary analysis on the supply of rural RNs in the United States.

Quantum effects in thermal reaction rates at metal surfaces.

There is wide interest in developing accurate theories for predicting rates of chemical reactions that occur at metal surfaces, especially for applications in industrial catalysis. Conventional methods contain many approximations that lack experimental validation. In practice, there are few reactions where sufficiently accurate experimental data exist to even allow meaningful comparisons to theory.