Publications by authors named "Audriy Jebet"
Article Synopsis
- * Recent studies indicate that human enolase 2 (ENO2) inhibitors, particularly a compound called HEX, show significant potential in targeting N. fowleri by blocking its glucose metabolism, making it toxic to these pathogens.
- * While HEX treatment extended the survival of infected rodents significantly compared to untreated controls, it did not fully eradicate the amoebae in their brains, indicating a need for further research to optimize its use as a treatment for primary amoebic meningoencephalitis (PAM).
Infections with the pathogenic free-living amoebae can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen.
View Article and Find Full Text PDFAlcohol-associated liver disease (ALD) is a serious public health problem with limited pharmacologic options. The goal of the current study was to investigate the efficacy of pharmacologic inhibition of soluble epoxide hydrolase (sEH), an enzyme involved in lipid metabolism, in experimental ALD, and to examine the underlying mechanisms. C57BL/6J male mice were subjected to acute-on-chronic ethanol (EtOH) feeding with or without the sEH inhibitor 4-[[trans-4-[[[[4-trifluoromethoxy phenyl]amino]carbonyl]-amino]cyclohexyl]oxy]-benzoic acid (TUCB).
View Article and Find Full Text PDFBackground: Tobacco smoke is a toxic gas-phase cocktail consisting of a broad range of organics, and free radical intermediates. The formation of smoke from a burning cigarette depends on a series of mechanisms, including generation of products by pyrolysis and combustion, aerosol formation, and physical mass transfer processes.
Methods: The current study simulates the deposition of particulate matter on the human lung surface by trapping the tobacco smoke particulates in situ on silica gel.